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G protein-coupled receptors: structure- and function-based drug discovery

文献类型：期刊论文

作者Yang, Dehua2,3; Zhou, Qingtong4; Labroska, Viktorija2,5; Qin, Shanshan6; Darbalaei, Sanaz2,5; Wu, Yiran6; Yuliantie, Elita2,5; Xie, Linshan6,7; Tao, Houchao6; Cheng, Jianjun6
刊名SIGNAL TRANSDUCTION AND TARGETED THERAPY
出版日期2021-01-08
卷号6期号:1页码:27
ISSN号2095-9907
DOI10.1038/s41392-020-00435-w
通讯作者Shui, Wenqing(shuiwq@shanghaitech.edu.cn) ; Jiang, Yi(yijiang@simm.ac.cn) ; Wang, Ming-Wei(mwwang@simm.ac.cn)
英文摘要As one of the most successful therapeutic target families, G protein-coupled receptors (GPCRs) have experienced a transformation from random ligand screening to knowledge-driven drug design. We are eye-witnessing tremendous progresses made recently in the understanding of their structure-function relationships that facilitated drug development at an unprecedented pace. This article intends to provide a comprehensive overview of this important field to a broader readership that shares some common interests in drug discovery.
WOS关键词MS-BINDING ASSAYS ; SELECTION-MASS SPECTROMETRY ; CRYO-EM STRUCTURE ; CRYSTALLIZING MEMBRANE-PROTEINS ; MOLECULAR-ORBITAL METHOD ; GLUCAGON-LIKE PEPTIDE-1 ; ALLOSTERIC MODULATION ; GLP-1 RECEPTOR ; BIASED AGONISM ; ADENOSINE A(1)
资助项目National Natural Science Foundation of China[81872915] ; National Natural Science Foundation of China[81773792] ; National Natural Science Foundation of China[81973373] ; National Natural Science Foundation of China[21704064] ; National Natural Science Foundation of China[31971362] ; National Natural Science Foundation of China[31971178] ; National Natural Science Foundation of China[31770796] ; National Science & Technology Major Project of China - Key New Drug Creation and Manufacturing Program[2018ZX09735-001] ; National Science & Technology Major Project of China - Key New Drug Creation and Manufacturing Program[2018ZX09711002-002-005] ; National Science & Technology Major Project of China - Key New Drug Creation and Manufacturing Program[2018ZX09711002-002-002] ; National Key Basic Research Program of China[2018YFA0507000] ; Novo Nordisk-CAS Research Fund grant[NNCAS-2017-1-CC] ; Belt and Road Master Fellowship program ; UCAS Scholarship for International Students ; CAS-TWAS President's Fellowship for International Doctoral Students
WOS研究方向Biochemistry & Molecular Biology ; Cell Biology
语种英语
出版者SPRINGERNATURE
WOS记录号WOS:000610372700001
源URL[http://119.78.100.183/handle/2S10ELR8/296004]  
专题中国科学院上海药物研究所
通讯作者Shui, Wenqing; Jiang, Yi; Wang, Ming-Wei
作者单位1.Fudan Univ, Sch Pharm, Shanghai 201203, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, Natl Ctr Drug Screening, Shanghai 201203, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China
4.Fudan Univ, Sch Basic Med Sci, Shanghai 200032, Peoples R China
5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
6.ShanghaiTech Univ, iHuman Inst, Shanghai 201210, Peoples R China
7.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China
推荐引用方式
GB/T 7714		 Yang, Dehua,Zhou, Qingtong,Labroska, Viktorija,et al. G protein-coupled receptors: structure- and function-based drug discovery[J]. SIGNAL TRANSDUCTION AND TARGETED THERAPY,2021,6(1):27.
APA Yang, Dehua.,Zhou, Qingtong.,Labroska, Viktorija.,Qin, Shanshan.,Darbalaei, Sanaz.,...&Wang, Ming-Wei.(2021).G protein-coupled receptors: structure- and function-based drug discovery.SIGNAL TRANSDUCTION AND TARGETED THERAPY,6(1),27.
MLA Yang, Dehua,et al."G protein-coupled receptors: structure- and function-based drug discovery".SIGNAL TRANSDUCTION AND TARGETED THERAPY 6.1(2021):27.

入库方式： OAI收割

来源：上海药物研究所

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