Targeted Drugs for Treatment of Pulmonary Arterial Hypertension: Past, Present, and Future Perspectives
文献类型：期刊论文
| 作者 | Zheng, Wei1,2; Wang, Zhen2 ; Jiang, Xiangrui2; Zhao, Qingjie2; Shen, Jingshan1,2
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| 刊名 | JOURNAL OF MEDICINAL CHEMISTRY
 |
| 出版日期 | 2020-12-24 |
| 卷号 | 63期号:24页码:15153-15186 |
| ISSN号 | 0022-2623 |
| DOI | 10.1021/acs.jmedchem.0c01093 |
| 通讯作者 | Shen, Jingshan(shenjingshan@simm.ac.cn) |
| 英文摘要 | Pulmonary arterial hypertension (PAH) is a devastating disease that can lead to right ventricular failure and premature death. Although approved drugs have been shown to be safe and effective, PAH remains a severe clinical condition, and the long-term survival of patients with PAH is still suboptimal. Thus, potential therapeutic targets and new agents to treat PAH are urgently needed. In recent years, a variety of related pathways and potential therapeutic targets have been found, which brings new hope for PAH therapy. In this perspective, not only are the marketed drugs used to treat PAH summarized but also the recently developed novel pharmaceutical therapies currently in clinical trials are discussed. Furthermore, the advances in natural products as potential treatment for PAH are also updated. |
| WOS关键词 | PROSTACYCLIN RECEPTOR AGONIST ; GUANYLATE-CYCLASE STIMULATOR ; VASCULAR REMODELING INHIBITION ; ANGIOTENSIN-ALDOSTERONE SYSTEM ; RIGHT-VENTRICULAR HYPERTROPHY ; TANSHINONE IIA SULFONATE ; NITRIC-OXIDE SYNTHASE ; RHO-KINASE INHIBITOR ; SMOOTH-MUSCLE-CELLS ; CONVERTING ENZYME 2 |
| 资助项目 | Strategic Priority Research Program of the CAS[XDA12040103] ; National Science & Technology Major Project Key New Drug Creation and Manufacturing Program, China[2018ZX09711002] ; Central Asian Center of Drug Discovery and Development Program of the CAS[CAM201901] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000603401900006 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/296069]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Shen, Jingshan |
| 作者单位 | 1.Univ Chinese Acad Sci, Sch Pharm, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zheng, Wei,Wang, Zhen,Jiang, Xiangrui,et al. Targeted Drugs for Treatment of Pulmonary Arterial Hypertension: Past, Present, and Future Perspectives[J]. JOURNAL OF MEDICINAL CHEMISTRY,2020,63(24):15153-15186. |
| APA | Zheng, Wei,Wang, Zhen,Jiang, Xiangrui,Zhao, Qingjie,&Shen, Jingshan.(2020).Targeted Drugs for Treatment of Pulmonary Arterial Hypertension: Past, Present, and Future Perspectives.JOURNAL OF MEDICINAL CHEMISTRY,63(24),15153-15186. |
| MLA | Zheng, Wei,et al."Targeted Drugs for Treatment of Pulmonary Arterial Hypertension: Past, Present, and Future Perspectives".JOURNAL OF MEDICINAL CHEMISTRY 63.24(2020):15153-15186. |
入库方式： OAI收割
来源：上海药物研究所
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