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  2. 上海药物研究所
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  4. 新药研究国家重点实验室
Guaianolide sesquiterpene lactones from Achillea millefolium L

文献类型：期刊论文

作者Li, Hongliang1,2,3; Li, Jun2,3; Liu, Mengqi1,4; Xie, Rongrong4; Zang, Yi1,4; Li, Jia1,4,5; Aisa, Haji Akber2,3
刊名PHYTOCHEMISTRY
出版日期2021-06-01
卷号186页码:9
关键词Achillea millefolium L. Asteraceae Guaianolide sesquiterpene lactones Millefoliumins A-G Melaogenesis Anti-inflammatory
ISSN号0031-9422
DOI10.1016/j.phytochem.2021.112733
通讯作者Li, Jia(jli@simm.ac.cn) ; Aisa, Haji Akber(haji@ms.xjb.ac.cn)
英文摘要Seven undescribed guaianolide sesquiterpene lactones, millefoliumins A-G, and five known analogues were isolated from the whole plant of Achillea millefolium L. growing in Xinjiang, China. Their structures were elucidated by analysis of spectroscopic data and comparison with literatures. The absolute configurations of millefoliumins A-G were determined by single-crystal X-ray crystallography, ECD data analysis along with quantum-chemical ECD calculations. The X-ray crystal structures of 8 alpha-angeloxy-1 beta,2 beta,4 beta,5 beta-diepoxy-10 beta-hydroxy-6 beta H,7 alpha H,11 beta H-12,6 alpha-guaianolide and 8 alpha-angeloxy-4 alpha,10 beta-dihydroxy-2-oxo-6 beta H,7 alpha H,11 beta H-1(5)-guaien-12,6 alpha-olide were reported for the first time, and the full C-13 NMR data of malaphyllidin were attributed for the first time. Millefoliumins F and G, and austricin could improve the melaogenesis by increasing the melanin content and tyrosinase activity of B16 melanoma cells. Millefoliumins A, C and D, and austricin showed anti-inflammatory activity against the NO production in LPS-induced RAW264.7 cells.
WOS关键词ANTIINFLAMMATORY ACTIVITY ; FLAVONOIDS ; MEDICINE ; EXTRACT ; FLOWER ; YARROW ; PLANTS
资助项目National Natural Science Foundation of China[U1703235] ; State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization[2017D04016] ; National Science & Technology Major Project Key New Drug Creation and Maufacturing Program[2019ZX09201001-003-001] ; National Science & Technology Major Project Key New Drug Creation and Maufacturing Program[2019ZX09201001-003-010]
WOS研究方向Biochemistry & Molecular Biology ; Plant Sciences
语种英语
WOS记录号WOS:000644703200015
出版者PERGAMON-ELSEVIER SCIENCE LTD
源URL[http://119.78.100.183/handle/2S10ELR8/296606]  
专题新药研究国家重点实验室
通讯作者Li, Jia; Aisa, Haji Akber
作者单位1.Univ Chinese Acad Sci, Beijing 10049, Peoples R China
2.Chinese Acad Sci, State Key Lab Basis Xinjiang Indigenous Med Plant, Xinjiang Tech Inst Phys & Chem, Urumqi 830011, Peoples R China
3.Chinese Acad Sci, Key Lab Plant Resources & Chem Arid Zone, Xinjiang Tech Inst Phys & Chem, Urumqi 830011, Peoples R China
4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
5.Pilot Natl Lab Marine Sci & Technol Qingdao, Open Studio Druggabil Res Marine Nat Prod, Qingdao 266237, Peoples R China
推荐引用方式
GB/T 7714		 Li, Hongliang,Li, Jun,Liu, Mengqi,et al. Guaianolide sesquiterpene lactones from Achillea millefolium L[J]. PHYTOCHEMISTRY,2021,186:9.
APA Li, Hongliang.,Li, Jun.,Liu, Mengqi.,Xie, Rongrong.,Zang, Yi.,...&Aisa, Haji Akber.(2021).Guaianolide sesquiterpene lactones from Achillea millefolium L.PHYTOCHEMISTRY,186,9.
MLA Li, Hongliang,et al."Guaianolide sesquiterpene lactones from Achillea millefolium L".PHYTOCHEMISTRY 186(2021):9.

入库方式： OAI收割

来源：上海药物研究所

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