中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Synthesis of new derivatives of alepterolic acid via click chemistry

文献类型:期刊论文

作者Jin, X. I. N.2,5; Cao, Jianguo1; Zhao, Qingjie3; Wang, Qi1; Guo, Hongmei2,5; Aisa, Haji Akber2; Huang, Guozheng2,4
刊名JOURNAL OF THE SERBIAN CHEMICAL SOCIETY
出版日期2021
卷号86期号:10页码:917-925
ISSN号0352-5139
关键词diterpenoid 1,2,3-triazole structural modification
DOI10.2298/JSC210316045J
通讯作者Aisa, Haji Akber(haji@ms.xjb.ac.cn) ; Huang, Guozheng(guozheng.huang@ahut.edu.cn)
英文摘要Alepterolic acid is a natural diterpenoid isolated from Aleuritopteris argentea (S. G. Gmel.) Fee, a fern with potential medicinal activity, used in China as a folk medicine to regulate menstruation and prevent cancer. Nevertheless, there are few reports about the structural modification of this natural product. With the wide application of 1,2,3-triazole derivatives in medicines, pesticides, functional materials, the synthesis of 1,2,3-triazoles derivatives has attracted the attention of synthetic chemists. In this article, 23 new derivatives of alepterolic acid combined with 1,2,3-triazole were designed and synthesized by esterification and click chemistry reaction in a fast, conventional and efficient way. All the products were obtained in good yields (72 to 97 %). The structure of these compounds was confirmed by H-1-, C-13-NMR and mass spectral data. The use of the easily available reactants and the common reaction conditions furnish an efficient method for the synthesis of alepterolic acid derivatives. The preparation of these compounds would enable further biological evaluation in the future.
WOS关键词1,2,3-TRIAZOLES ; CYCLOADDITION ; DESIGN ; AGENTS
资助项目Anhui University of Technology ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDA12040322]
WOS研究方向Chemistry
语种英语
出版者SERBIAN CHEMICAL SOC
WOS记录号WOS:000701832600002
源URL[http://119.78.100.183/handle/2S10ELR8/297449]  
专题中国科学院上海药物研究所
通讯作者Aisa, Haji Akber; Huang, Guozheng
作者单位1.Shanghai Normal Univ, Coll Life Sci, Shanghai 201418, Peoples R China
2.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Chem Arid Zone, Urumqi 830011, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China
4.Anhui Univ Technol, Coll Chem & Chem Engn, Maanshan 243002, Peoples R China
5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714
Jin, X. I. N.,Cao, Jianguo,Zhao, Qingjie,et al. Synthesis of new derivatives of alepterolic acid via click chemistry[J]. JOURNAL OF THE SERBIAN CHEMICAL SOCIETY,2021,86(10):917-925.
APA Jin, X. I. N..,Cao, Jianguo.,Zhao, Qingjie.,Wang, Qi.,Guo, Hongmei.,...&Huang, Guozheng.(2021).Synthesis of new derivatives of alepterolic acid via click chemistry.JOURNAL OF THE SERBIAN CHEMICAL SOCIETY,86(10),917-925.
MLA Jin, X. I. N.,et al."Synthesis of new derivatives of alepterolic acid via click chemistry".JOURNAL OF THE SERBIAN CHEMICAL SOCIETY 86.10(2021):917-925.

入库方式: OAI收割

来源:上海药物研究所

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