中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Design and Synthesis of Alkyl Phenols Inhibitors of Death Associated Apoptotic Protein Kinase 2 (DRAK2)

文献类型:期刊论文

作者Zheng Zhang1,2; Dai Chengqiu1,3; Wu Honghong1,2; Li Jingya1,2; Nan Fajun1,2
刊名CHINESE JOURNAL OF ORGANIC CHEMISTRY
出版日期2021-08-25
卷号41期号:8页码:3204-3213
关键词death associated apoptotic protein kinase 2 diabetes alkylphenols inhibitors
ISSN号0253-2786
DOI10.6023/cjoc202103056
通讯作者Li Jingya(jyli@simm.ac.cn) ; Nan Fajun(fjnan@simm.ac.cn)
英文摘要Death associated apoptotic protein kinase 2 (DRAK2) is a threonine/serine kinase and a member of the death-associated protein kinase (DAPK) family. Under the action of external stimuli, its overexpression has the ability to induce apoptosis. High glucose, high fat, and certain cellular inflammatory factors can induce the high expression of DRAK2, thereby causing pancreatic beta-cell apoptosis. DRAK2 may play a mediating role in the process. Therefore, small molecule inhibitors targeting DRAK2 own good development prospects to treat diabetes. In this work, more than 20 active compounds were obtained through structural modification of the alkylphenols compound 8a, and the structure-activity relationship between them was preliminarily determined.
WOS关键词SERINE/THREONINE KINASE ; DISCOVERY ; DERIVATIVES
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000702991300023
出版者SCIENCE PRESS
源URL[http://119.78.100.183/handle/2S10ELR8/297520]  
专题中国科学院上海药物研究所
通讯作者Li Jingya; Nan Fajun
作者单位1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
2.Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
3.Hangzhou Inst Adv Study, Hangzhou 310024, Peoples R China
推荐引用方式
GB/T 7714
Zheng Zhang,Dai Chengqiu,Wu Honghong,et al. Design and Synthesis of Alkyl Phenols Inhibitors of Death Associated Apoptotic Protein Kinase 2 (DRAK2)[J]. CHINESE JOURNAL OF ORGANIC CHEMISTRY,2021,41(8):3204-3213.
APA Zheng Zhang,Dai Chengqiu,Wu Honghong,Li Jingya,&Nan Fajun.(2021).Design and Synthesis of Alkyl Phenols Inhibitors of Death Associated Apoptotic Protein Kinase 2 (DRAK2).CHINESE JOURNAL OF ORGANIC CHEMISTRY,41(8),3204-3213.
MLA Zheng Zhang,et al."Design and Synthesis of Alkyl Phenols Inhibitors of Death Associated Apoptotic Protein Kinase 2 (DRAK2)".CHINESE JOURNAL OF ORGANIC CHEMISTRY 41.8(2021):3204-3213.

入库方式: OAI收割

来源:上海药物研究所

浏览0
下载0
收藏0
其他版本

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。