Design and Synthesis of Alkyl Phenols Inhibitors of Death Associated Apoptotic Protein Kinase 2 (DRAK2)
文献类型：期刊论文
| 作者 | Zheng Zhang1,2; Dai Chengqiu1,3; Wu Honghong1,2; Li Jingya1,2 ; Nan Fajun1,2
|
| 刊名 | CHINESE JOURNAL OF ORGANIC CHEMISTRY
 |
| 出版日期 | 2021-08-25 |
| 卷号 | 41期号:8页码:3204-3213 |
| 关键词 | death associated apoptotic protein kinase 2 diabetes alkylphenols inhibitors |
| ISSN号 | 0253-2786 |
| DOI | 10.6023/cjoc202103056 |
| 通讯作者 | Li Jingya(jyli@simm.ac.cn) ; Nan Fajun(fjnan@simm.ac.cn) |
| 英文摘要 | Death associated apoptotic protein kinase 2 (DRAK2) is a threonine/serine kinase and a member of the death-associated protein kinase (DAPK) family. Under the action of external stimuli, its overexpression has the ability to induce apoptosis. High glucose, high fat, and certain cellular inflammatory factors can induce the high expression of DRAK2, thereby causing pancreatic beta-cell apoptosis. DRAK2 may play a mediating role in the process. Therefore, small molecule inhibitors targeting DRAK2 own good development prospects to treat diabetes. In this work, more than 20 active compounds were obtained through structural modification of the alkylphenols compound 8a, and the structure-activity relationship between them was preliminarily determined. |
| WOS关键词 | SERINE/THREONINE KINASE ; DISCOVERY ; DERIVATIVES |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000702991300023 |
| 出版者 | SCIENCE PRESS |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/297520]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Li Jingya; Nan Fajun |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 3.Hangzhou Inst Adv Study, Hangzhou 310024, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zheng Zhang,Dai Chengqiu,Wu Honghong,et al. Design and Synthesis of Alkyl Phenols Inhibitors of Death Associated Apoptotic Protein Kinase 2 (DRAK2)[J]. CHINESE JOURNAL OF ORGANIC CHEMISTRY,2021,41(8):3204-3213. |
| APA | Zheng Zhang,Dai Chengqiu,Wu Honghong,Li Jingya,&Nan Fajun.(2021).Design and Synthesis of Alkyl Phenols Inhibitors of Death Associated Apoptotic Protein Kinase 2 (DRAK2).CHINESE JOURNAL OF ORGANIC CHEMISTRY,41(8),3204-3213. |
| MLA | Zheng Zhang,et al."Design and Synthesis of Alkyl Phenols Inhibitors of Death Associated Apoptotic Protein Kinase 2 (DRAK2)".CHINESE JOURNAL OF ORGANIC CHEMISTRY 41.8(2021):3204-3213. |
入库方式： OAI收割
来源：上海药物研究所
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