Catalytic System-Controlled Divergent Reaction Strategies for the Construction of Diversified Spiropyrazolone Skeletons from Pyrazolidinones and Diazopyrazolones
文献类型：期刊论文
| 作者 | Fang, Feifei1,2,3,4; Hu, Shulei1,2,3,4; Li, Chunpu1,4; Wang, Qian1,4; Wang, Run1,4; Han, Xu1,4; Zhou, Yu1,4 ; Liu, Hong1,2,3,4
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| 刊名 | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
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| 出版日期 | 2021-08-18 |
| 页码 | 8 |
| ISSN号 | 1433-7851 |
| 关键词 | [n+1] annulation C(sp(3))-H bond activation N-N bond activation pyrazolidinones spiropyrazolones |
| DOI | 10.1002/anie.202105857 |
| 通讯作者 | Zhou, Yu(zhouyu@simm.ac.cn) ; Liu, Hong(hliu@simm.ac.cn) |
| 英文摘要 | A catalytic system-controlled divergent reaction strategy was here reported to construct four types of intriguing spiroheterocyclic skeletons from simple and readily available starting materials via a precise chemical bond activation/[n+1] annulation cascade. The tetraazaspiroheterocyclic and trizazspiroheterocyclic scaffolds could be independently constructed by a selective N-N bond activation/[n+1] annulation cascade, a C(sp(2))-H activation/[4+1] annulation and a novel tandem C(sp(2))-H/C(sp(3))-H bond activation/[4+1] annulation strategy, along with a broad scope of substrates, moderate to excellent yields and valuable transformations. More importantly, in these transformations, we are the first time to capture a N-N bond activation and a C(sp(3))-H bond activation of pyrazolidinones under different catalytic system. |
| WOS关键词 | C-H ACTIVATION ; PROPARGYL ALCOHOLS ; INSERTION REACTION ; INHIBITORS ; EFFICIENT ; ANNULATION ; MOLECULES ; ALKALOIDS ; PROGRESS ; CASCADE |
| 资助项目 | National Natural Science Foundation of China[21977106] ; National Natural Science Foundation of China[21632008] ; National Natural Science Foundation of China[81620108027] ; Shanghai Science and Technology Development Funds[19431901000] ; Shanghai Science and Technology Development Funds[19431901200] ; Science and Technology Commission of Shanghai Municipality[18JC1411304] ; Youth Innovation Promotion Association CAS |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| WOS记录号 | WOS:000685664700001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/298107]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Zhou, Yu; Liu, Hong |
| 作者单位 | 1.Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Sch Pharmaceut Sci & Technol, Hangzhou 310024, Peoples R China 2.China Pharmaceut Univ, State Key Lab Nat Med, 24 Tong Jia Xiang, Nanjing 210009, Jiangsu, Peoples R China 3.China Pharmaceut Univ, Dept Med Chem, 24 Tong Jia Xiang, Nanjing 210009, Jiangsu, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Chong Zhi Rd, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Fang, Feifei,Hu, Shulei,Li, Chunpu,et al. Catalytic System-Controlled Divergent Reaction Strategies for the Construction of Diversified Spiropyrazolone Skeletons from Pyrazolidinones and Diazopyrazolones[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2021:8. |
| APA | Fang, Feifei.,Hu, Shulei.,Li, Chunpu.,Wang, Qian.,Wang, Run.,...&Liu, Hong.(2021).Catalytic System-Controlled Divergent Reaction Strategies for the Construction of Diversified Spiropyrazolone Skeletons from Pyrazolidinones and Diazopyrazolones.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,8. |
| MLA | Fang, Feifei,et al."Catalytic System-Controlled Divergent Reaction Strategies for the Construction of Diversified Spiropyrazolone Skeletons from Pyrazolidinones and Diazopyrazolones".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021):8. |
入库方式： OAI收割
来源：上海药物研究所
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