Arabidopsis histone H3K4 demethylase JMJ17 functions in dehydration stress response
文献类型：期刊论文
| 作者 | Huang, Shuangzhan; Zhang, Ai; Jin, Jing Bo2; Zhao, Bo3,4; Wang, Tian-Jing; Wu, Yifan; Wang, Shuang; Liu, Yutong; Wang, Jie; Guo, Peng |
| 刊名 | NEW PHYTOLOGIST
 |
| 出版日期 | 2019 |
| 卷号 | 223期号:3页码:1372-1387 |
| 关键词 | abiotic stress abscisic acid (ABA) Arabidopsis thaliana dehydration stress histone demethylation transcriptional regulation |
| ISSN号 | 0028-646X |
| DOI | 10.1111/nph.15874 |
| 文献子类 | Article |
| 英文摘要 | Under dehydration in plants, antagonistic activities of histone 3 lysine 4 (H3K4) methyltransferase and histone demethylase maintain a dynamic and homeostatic state of gene expression by orientating transcriptional reprogramming toward growth or stress tolerance. However, the histone demethylase that specifically controls histone methylation homeostasis under dehydration stress remains unknown. Here, we document that a histone demethylase, JMJ17, belonging to the KDM5/JARID1 family, plays crucial roles in response to dehydration stress and abscisic acid (ABA) in Arabidopsis thaliana. jmj17 loss-of-function mutants displayed dehydration stress tolerance and ABA hypersensitivity in terms of stomatal closure. JMJ17 specifically demethylated H3K4me1/2/3 via conserved iron-binding amino acids in vitro and in vivo. Moreover, H3K4 demethylase activity of JMJ17 was required for dehydration stress response. Systematic combination of genome-wide chromatin immunoprecipitation coupled with massively parallel DNA sequencing (ChIP-seq) and RNA-sequencing (RNA-seq) analyses revealed that a loss-of-function mutation in JMJ17 caused an ectopic increase in genome-wide H3K4me3 levels and activated a plethora of dehydration stress-responsive genes. Importantly, JMJ17 bound directly to the chromatin of OPEN STOMATA 1 (OST1) and demethylated H3K4me3 for the regulation of OST1 mRNA abundance, thereby modulating the dehydration stress response. Our results demonstrate a new function of a histone demethylase under dehydration stress in plants. |
| 学科主题 | Plant Sciences |
| 出版地 | HOBOKEN |
| 电子版国际标准刊号 | 1469-8137 |
| WOS关键词 | ABSCISIC-ACID RESPONSES ; TRANS-GOLGI NETWORK ; TRANSCRIPTION FACTORS ; CENTRAL VACUOLE ; PROTEIN-KINASE ; GUARD-CELLS ; CHROMATIN ; TRITHORAX ; MEMBRANE ; MUTANTS |
| WOS研究方向 | Plant Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000475918000029 |
| 出版者 | WILEY |
| 资助机构 | Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities [#2412018BJ002] Funding Source: Medline ; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31601311, 31771352] Funding Source: Medline ; Natural Science Foundation of Jilin Province of China [20180101233JC] Funding Source: Medline ; National Key Research and Development Program of China [2016YFD0102003] Funding Source: Medline |
| 源URL | [http://ir.ibcas.ac.cn/handle/2S10CLM1/19753]  |
| 专题 | 中科院植物分子生理学重点实验室 |
| 作者单位 | 1.Univ Texas Austin, Dept Mol Biosci, Austin, TX 78712 USA 2.Northeast Normal Univ, Minist Educ MOE, Key Lab Mol Epigenet, Changchun 130024, Jilin, Peoples R China 3.Univ Texas Austin, Inst Cellular & Mol Biol, Austin, TX 78712 USA 4.Chinese Acad Sci, Inst Bot, Key Lab Mol Physiol, Beijing 100093, Peoples R China |
| 推荐引用方式 GB/T 7714 | Huang, Shuangzhan,Zhang, Ai,Jin, Jing Bo,et al. Arabidopsis histone H3K4 demethylase JMJ17 functions in dehydration stress response[J]. NEW PHYTOLOGIST,2019,223(3):1372-1387. |
| APA | Huang, Shuangzhan.,Zhang, Ai.,Jin, Jing Bo.,Zhao, Bo.,Wang, Tian-Jing.,...&Xu, Zheng-Yi.(2019).Arabidopsis histone H3K4 demethylase JMJ17 functions in dehydration stress response.NEW PHYTOLOGIST,223(3),1372-1387. |
| MLA | Huang, Shuangzhan,et al."Arabidopsis histone H3K4 demethylase JMJ17 functions in dehydration stress response".NEW PHYTOLOGIST 223.3(2019):1372-1387. |
入库方式： OAI收割
来源：植物研究所
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