Oxidative stress-inducing effects of various urban PM2.5 road dust on human lung epithelial cells among 10 Chinese megacities
文献类型：期刊论文
| 作者 | Sun, Jian1; Yu, Jinjin2; Shen, Zhenxing1; Niu, Xinyi3; Wang, Diwei1; Wang, Xin7; Xu, Hongmei1; Chuang, Hsiao-Chi5; Cao, Junji6; Ho, Kin-Fai4 |
| 刊名 | ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
 |
| 出版日期 | 2021-11-01 |
| 卷号 | 224页码:10 |
| ISSN号 | 0147-6513 |
| 关键词 | Urban fugitive dust ROS PAH Heavy metal Source apportionment |
| DOI | 10.1016/j.ecoenv.2021.112680 |
| 通讯作者 | Shen, Zhenxing(zxshen@mail.xjtu.edu.cn) |
| 英文摘要 | PM2.5 Road dust samples were collected from 10 representative cities in southern and northern China for examination of chemical components and oxidative stress levels in A549 cells. Downtown road dust was abundance of heavy metals, EC and PAHs compared to nondowntown road dust. Source apportionment also revealed the relative higher contribution of vehicle emission to downtown (35.8%) than nondowntown road dust (25.5%). Consequently, downtown road dust induced much higher intracellular reactive oxidative species (ROS) levels than that from nondowntown (p < 0.05). This study highlights that the ROS-inducing capacity of road dust in China is lower at lower latitudes, which resulted in a significantly higher ROS-inducing capacity of road dust from northern cities than southern ones. Hotspot analysis demonstrated that heavy metals (i.e., Cr, Zn, Cu and Pb) in road dust were the most closely associated with ROS production in A549 cells. Vehicle emission and combustion emission in road dust were identified to be correlated with cellular ROS production. The findings highlight the ROS-inducing effect of PM2.5 road dust and also serve as a reference to make the targeted solutions for urban road dust pollution control, especially from a public health perspective. |
| WOS关键词 | POLYCYCLIC AROMATIC-HYDROCARBONS ; CHEMICAL SOURCE PROFILES ; FINE PARTICULATE MATTER ; SOURCE APPORTIONMENT ; FUGITIVE DUST ; HEAVY-METALS ; ASIAN DUST ; HEALTH-RISKS ; PM10 ; PAHS |
| 资助项目 | Natural Science Foundation of Shaanxi Province, China[2019JQ-386] ; Natural Science Foundation of Shaanxi Province, China[2019JM-318] ; China Postdoctoral Science Foundation[2021M692549] |
| WOS研究方向 | Environmental Sciences & Ecology ; Toxicology |
| 语种 | 英语 |
| 出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE |
| WOS记录号 | WOS:000693097300007 |
| 资助机构 | Natural Science Foundation of Shaanxi Province, China ; China Postdoctoral Science Foundation |
| 源URL | [http://ir.ieecas.cn/handle/361006/16966]  |
| 专题 | 地球环境研究所_粉尘与环境研究室 |
| 通讯作者 | Shen, Zhenxing |
| 作者单位 | 1.Xi An Jiao Tong Univ, Dept Environm Sci & Engn, Xian 710049, Peoples R China 2.Xi An Jiao Tong Univ, Sch Pharm, Xian 710061, Peoples R China 3.Xi An Jiao Tong Univ, Sch Human Settlements & Civil Engn, Xian 710049, Peoples R China 4.Chinese Univ Hong Kong, Jockey Club Sch Publ Hlth & Primary Care, Hong Kong, Peoples R China 5.Taipei Med Univ, Coll Med, Sch Resp Therapy, Taipei, Taiwan 6.Chinese Acad Sci, Inst Earth Environm, Key Lab Aerosol Chem & Phys, Xian 710075, Peoples R China 7.Georgia Inst Technol, Sch Chem & Biomol Engn, Atlanta, GA 30332 USA |
| 推荐引用方式 GB/T 7714 | Sun, Jian,Yu, Jinjin,Shen, Zhenxing,et al. Oxidative stress-inducing effects of various urban PM2.5 road dust on human lung epithelial cells among 10 Chinese megacities[J]. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,2021,224:10. |
| APA | Sun, Jian.,Yu, Jinjin.,Shen, Zhenxing.,Niu, Xinyi.,Wang, Diwei.,...&Ho, Kin-Fai.(2021).Oxidative stress-inducing effects of various urban PM2.5 road dust on human lung epithelial cells among 10 Chinese megacities.ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,224,10. |
| MLA | Sun, Jian,et al."Oxidative stress-inducing effects of various urban PM2.5 road dust on human lung epithelial cells among 10 Chinese megacities".ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY 224(2021):10. |
入库方式： OAI收割
来源：地球环境研究所
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