Cediranib Induces Apoptosis, G1 Phase Cell Cycle Arrest, and Autophagy in Non-Small-Cell Lung Cancer Cell A549 In Vitro
文献类型：期刊论文
| 作者 | Guo, Menghuan3,4; Liu, Zhiyuan5; Si, Jing1,3 ; Zhang, Jinhua1,3; Zhao, Jin2; Guo, Zhong2; Xie, Yi1,3; Zhang, Hong1,3; Gan, Lu1,3
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| 刊名 | BIOMED RESEARCH INTERNATIONAL
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| 出版日期 | 2021-03-30 |
| 卷号 | 2021页码:11 |
| ISSN号 | 2314-6133 |
| DOI | 10.1155/2021/5582648 |
| 通讯作者 | Zhang, Hong(zhanghong@impcas.ac.cn) ; Gan, Lu(ganl@impcas.ac.cn) |
| 英文摘要 | Lung cancer remains the leading cause of cancer death worldwide. Late diagnosis, chemoresistance, and metastasis are the main reasons for the high mortality rate of lung cancer. Therefore, the development of other treatments is urgent. Cediranib (CED), a vascular endothelial growth factor receptor (VEGFR) kinase inhibitor, shows promising antitumour activities in various cancers including lung cancer. Here, we explored the effects and the underlying molecular mechanism of CED on non-small-cell lung cancer (NSCLC) cell line A549 cells in vitro. Our results show that CED could inhibit A549 cell proliferation and cloning formation. Meanwhile, G1 phase cell cycle arrest was also found, as featured by the increased proportion of G1 phase cells as well as the reduction of G1 phase relative proteins CDK4/cyclin D1 and CDK2/cyclin E. Moreover, the ratio of LC3-II/LC3-I was elevated significantly in CED-treated groups compared with the controls. Furthermore, the expression of p-Akt, p-P38, p-Erk1/2, and p-mTOR proteins was decreased obviously in the treatment groups. These results suggest that CED could induce apoptosis and G1 phase cell cycle arrest in A549 cells. Meanwhile, CED may induce autophagy through MAPK/Erk1/2 and Akt/mTOR signal pathway in A549 cells. |
| 资助项目 | Ministry of Science and Technology National Key RD Project[2018YFE0205100] ; National Natural Science Foundation of China[81960337] ; National Natural Science Foundation of China[12065001] ; Fundamental Research Funds for the Central Universities[31920160048] ; Science and Technology Plan Project of Chengguan district[2019RCCX0071] |
| WOS研究方向 | Biotechnology & Applied Microbiology ; Research & Experimental Medicine |
| 语种 | 英语 |
| WOS记录号 | WOS:000640307900007 |
| 出版者 | HINDAWI LTD |
| 资助机构 | Ministry of Science and Technology National Key RD Project ; National Natural Science Foundation of China ; Fundamental Research Funds for the Central Universities ; Science and Technology Plan Project of Chengguan district |
| 源URL | [http://119.78.100.186/handle/113462/137598]  |
| 专题 | 中国科学院近代物理研究所 |
| 通讯作者 | Zhang, Hong; Gan, Lu |
| 作者单位 | 1.Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Peoples R China 2.Northwest Minzu Univ, Med Coll, Lanzhou 730030, Gansu, Peoples R China 3.Adv Energy Sci & Technol Guangdong Lab, Huizhou 516029, Guangdong, Peoples R China 4.Lanzhou Univ, Sch Pharm, Lanzhou 730000, Gansu, Peoples R China 5.Northwest Minzu Univ, Coll Chem Engn, Gansu Key Lab Environm Friendly Composites & Biom, Lanzhou 730030, Gansu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Guo, Menghuan,Liu, Zhiyuan,Si, Jing,et al. Cediranib Induces Apoptosis, G1 Phase Cell Cycle Arrest, and Autophagy in Non-Small-Cell Lung Cancer Cell A549 In Vitro[J]. BIOMED RESEARCH INTERNATIONAL,2021,2021:11. |
| APA | Guo, Menghuan.,Liu, Zhiyuan.,Si, Jing.,Zhang, Jinhua.,Zhao, Jin.,...&Gan, Lu.(2021).Cediranib Induces Apoptosis, G1 Phase Cell Cycle Arrest, and Autophagy in Non-Small-Cell Lung Cancer Cell A549 In Vitro.BIOMED RESEARCH INTERNATIONAL,2021,11. |
| MLA | Guo, Menghuan,et al."Cediranib Induces Apoptosis, G1 Phase Cell Cycle Arrest, and Autophagy in Non-Small-Cell Lung Cancer Cell A549 In Vitro".BIOMED RESEARCH INTERNATIONAL 2021(2021):11. |
入库方式： OAI收割
来源：近代物理研究所
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