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Crosstalk of the Caspase Family and Mammalian Target of Rapamycin Signaling

文献类型：期刊论文

作者Yan, Junfang1,2,3,4,5; Xie, Yi1,2,3,4; Si, Jing1,2,3,4; Gan, Lu1,2,3,4; Li, Hongyan1,2,3,4; Sun, Chao1,2,3,4; Di, Cuixia1,2,3,4; Zhang, Jinhua1,2,3,4,5; Huang, Guomin1,2,3,4,5; Zhang, Xuetian1,2,3,4,5
刊名INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
出版日期2021
卷号22期号:2页码:19
关键词the caspase family mTOR signaling cell fate interplay
DOI10.3390/ijms22020817
通讯作者Xie, Yi(xieyi@impcas.ac.cn) ; Zhang, Hong(zhangh@impcas.ac.cn)
英文摘要Cell can integrate the caspase family and mammalian target of rapamycin (mTOR) signaling in response to cellular stress triggered by environment. It is necessary here to elucidate the direct response and interaction mechanism between the two signaling pathways in regulating cell survival and determining cell fate under cellular stress. Members of the caspase family are crucial regulators of inflammation, endoplasmic reticulum stress response and apoptosis. mTOR signaling is known to mediate cell growth, nutrition and metabolism. For instance, over-nutrition can cause the hyperactivation of mTOR signaling, which is associated with diabetes. Nutrition deprivation can inhibit mTOR signaling via SH3 domain-binding protein 4. It is striking that Ras GTPase-activating protein 1 is found to mediate cell survival in a caspase-dependent manner against increasing cellular stress, which describes a new model of apoptosis. The components of mTOR signaling-raptor can be cleaved by caspases to control cell growth. In addition, mTOR is identified to coordinate the defense process of the immune system by suppressing the vitality of caspase-1 or regulating other interferon regulatory factors. The present review discusses the roles of the caspase family or mTOR pathway against cellular stress and generalizes their interplay mechanism in cell fate determination.
资助项目National Key R&D Program of China[2018YFE0205100] ; Key Program of the National Natural Sciences Foundation of China[U1632270] ; Science and Technology Talent Project in Lanzhou[2018RC-66] ; Scientific Technology Research Projects of Gansu Province[20JR5RA551]
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
语种英语
WOS记录号WOS:000611289800001
出版者MDPI
资助机构National Key R&D Program of China ; Key Program of the National Natural Sciences Foundation of China ; Science and Technology Talent Project in Lanzhou ; Scientific Technology Research Projects of Gansu Province
源URL[http://119.78.100.186/handle/113462/138103]  
专题中国科学院近代物理研究所
通讯作者Xie, Yi; Zhang, Hong
作者单位1.Chinese Acad Sci, Inst Modern Phys, 509 Nanchang Rd, Lanzhou 730000, Peoples R China
2.Adv Energy Sci & Technol Guangdong Lab, Huizhou 516029, Peoples R China
3.Chinese Acad Sci, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou 730000, Peoples R China
4.Key Lab Heavy Ion Radiat Med Gansu Prov, Lanzhou 730000, Peoples R China
5.Univ Chinese Acad Sci, Coll Life Sci, Beijing 101408, Peoples R China
推荐引用方式
GB/T 7714		 Yan, Junfang,Xie, Yi,Si, Jing,et al. Crosstalk of the Caspase Family and Mammalian Target of Rapamycin Signaling[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2021,22(2):19.
APA Yan, Junfang.,Xie, Yi.,Si, Jing.,Gan, Lu.,Li, Hongyan.,...&Zhang, Hong.(2021).Crosstalk of the Caspase Family and Mammalian Target of Rapamycin Signaling.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,22(2),19.
MLA Yan, Junfang,et al."Crosstalk of the Caspase Family and Mammalian Target of Rapamycin Signaling".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 22.2(2021):19.

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来源：近代物理研究所

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