Radiosensitization Effect of AGuIX, a Gadolinium-Based Nanoparticle, in Nonsmall Cell Lung Cancer
文献类型:期刊论文
作者 | Du, Yanan1,2,3; Sun, Hao2,3; Lux, Francois4,5; Xie, Yi6; Du, Liqing2,3; Xu, Chang2,3; Zhang, Hong6; He, Ningning2,3; Wang, Jinhan2,3; Liu, Yang2,3 |
刊名 | ACS APPLIED MATERIALS & INTERFACES |
出版日期 | 2020-12-23 |
卷号 | 12期号:51页码:56874-56885 |
ISSN号 | 1944-8244 |
关键词 | NSCLC cell lines AGuIX nanoparticles irradiation radiosensitization effect DNA damage repair |
DOI | 10.1021/acsami.0c16548 |
通讯作者 | Wang, Yan(wangyan@irm-cams.ac.cn) ; Liu, Qiang(liuqiang@irm-cams.ac.cn) |
英文摘要 | Radiotherapy is the main treatment for cancer patients. A major concern in radiotherapy is the radiation resistance of some tumors, such as human nonsmall cell lung cancer. However, the radiation dose delivered to the tumors is often limited by the possibility of collateral damage to surrounding healthy tissues. A new and efficient gadolinium-based nanoparticle, AGuIX, has recently been developed for magnetic resonance imaging-guided radiotherapy and has been proven to act as an efficient radiosensitizer. The amplified radiation effects of AGuIX nanoparticles appear to be due to the emission of low-energy photoelectrons and Auger electron interactions. We demonstrated that AGuIX nanoparticles exacerbated radiation-induced DNA double-strand break damage and reduced DNA repair in the H1299 nonsmall cell lung cancer cell line. Furthermore, we observed a significant improvement in tumor cell damage and growth suppression, under radiation therapy, with the AGuIX nanoparticles in a H1299 mouse xenograft model. This study paves the way for research into the radiosensitization mechanism of AGuIX nanoparticles and provides a scientific basis for the use of AGuIX nanoparticles as radiosensitizing drugs. |
WOS关键词 | DNA-DAMAGE RESPONSE ; ATM PROTEIN-KINASE ; IONIZING-RADIATION ; OXIDATIVE STRESS ; RADIOTHERAPY ; ACTIVATION ; RADIORESISTANCE ; MECHANISMS ; CLEARANCE ; CARCINOMA |
资助项目 | National Natural Science Foundation of China[31670859] ; National Natural Science Foundation of China[31971168] ; National Natural Science Foundation of China[31800703] ; Fundamental Research Funds for the Central Universities[3332018158] ; CAMS Innovation Fund for Medical Science[2017-I2M-1-016] ; China Postdoctoral Science Foundation[2018M630106] ; Natural Science Foundation of Tianjin[18JCYBJC26800] ; Natural Science Foundation of Tianjin[18JCQNJC12300] ; Nonprofit Central Research Institute Fund of Chinese Academy of Medical Sciences[2017-1001-08] |
WOS研究方向 | Science & Technology - Other Topics ; Materials Science |
语种 | 英语 |
出版者 | AMER CHEMICAL SOC |
WOS记录号 | WOS:000603397200019 |
资助机构 | National Natural Science Foundation of China ; Fundamental Research Funds for the Central Universities ; CAMS Innovation Fund for Medical Science ; China Postdoctoral Science Foundation ; Natural Science Foundation of Tianjin ; Nonprofit Central Research Institute Fund of Chinese Academy of Medical Sciences |
源URL | [http://119.78.100.186/handle/113462/138196] |
专题 | 中国科学院近代物理研究所 |
通讯作者 | Wang, Yan; Liu, Qiang |
作者单位 | 1.Tianjin Ctr Dis Control & Prevent, Tianjin 300011, Peoples R China 2.Chinese Acad Med Sci, Inst Radiat Med, Tianjin 300192, Peoples R China 3.Chinese Acad Med Sci, Peking Union Med Coll, Tianjin 300192, Peoples R China 4.Lyon Univ, Lyon1 Univ, Inst Light & Mater, UMR5306,CNRS, F-69100 Villeurbanne, France 5.NH TherAguix SAS, NH TherAguix, F-69100 Villeurbanne, France 6.Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Peoples R China |
推荐引用方式 GB/T 7714 | Du, Yanan,Sun, Hao,Lux, Francois,et al. Radiosensitization Effect of AGuIX, a Gadolinium-Based Nanoparticle, in Nonsmall Cell Lung Cancer[J]. ACS APPLIED MATERIALS & INTERFACES,2020,12(51):56874-56885. |
APA | Du, Yanan.,Sun, Hao.,Lux, Francois.,Xie, Yi.,Du, Liqing.,...&Tillement, Olivier.(2020).Radiosensitization Effect of AGuIX, a Gadolinium-Based Nanoparticle, in Nonsmall Cell Lung Cancer.ACS APPLIED MATERIALS & INTERFACES,12(51),56874-56885. |
MLA | Du, Yanan,et al."Radiosensitization Effect of AGuIX, a Gadolinium-Based Nanoparticle, in Nonsmall Cell Lung Cancer".ACS APPLIED MATERIALS & INTERFACES 12.51(2020):56874-56885. |
入库方式: OAI收割
来源:近代物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。