Clinical Efficacy and Safety of Proton and Carbon Ion Radiotherapy for Prostate Cancer: A Systematic Review and Meta-Analysis
文献类型：期刊论文
| 作者 | Li, Meixuan2,3,4,9; Li, Xiuxia2,3,4,9; Yao, Liang5 ; Han, Xue1; Yan, Wenlong6; Liu, Yujun6; Fu, Yiwen1; Wang, Yakun6; Huang, Min6; Zhang, Qiuning7,8
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| 刊名 | FRONTIERS IN ONCOLOGY
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| 出版日期 | 2021-10-12 |
| 卷号 | 11页码:15 |
| ISSN号 | 2234-943X |
| 关键词 | proton beam therapy carbon ion radiotherapy prostate cancer efficacy safety meta-analysis |
| DOI | 10.3389/fonc.2021.709530 |
| 通讯作者 | Wang, Xiaohu(yangkh-ebm@lzu.edu.cn) ; Yang, Kehu(ebm2019@126.com) |
| 英文摘要 | Background:& nbsp;Carbon ion radiotherapy (CIRT) and proton beam therapy (PBT) are promising methods for prostate cancer, however, the consensus of an increasing number of studies has not been reached. We aimed to provide systematic evidence for evaluating the efficacy and safety of CIRT and PBT for prostate cancer by comparing photon radiotherapy.
Materials and Methods:& nbsp;We searched for studies focusing on CIRT and PBT for prostate cancer in four online databases until July 2021. Two independent reviewers assessed the quality of included studies and used the GRADE approach to rate the quality of evidence. R 4.0.2 software was used to conduct the meta-analysis. A meta-regression test was performed based on the study design and tumor stage of each study. Results:& nbsp;A total of 33 studies including 13 CIRT- and 20 PBT-related publications, involving 54,101, participants were included. The quality of the included studies was found to be either low or moderate quality. Random model single-arm meta-analysis showed that both the CIRT and PBT have favorable efficacy and safety, with similar 5-year overall survival (OS) (94 vs 92%), the incidence of grade 2 or greater acute genitourinary (AGU) toxicity (5 vs 13%), late genitourinary (LGU) toxicity (4 vs 5%), acute gastrointestinal (AGI) toxicity (1 vs 1%), and late gastrointestinal (LGI) toxicity (2 vs 4%). However, compared with CIRT and PBT, photon radiotherapy was associated with lower 5-year OS (72-73%) and a higher incidence of grade 2 or greater AGU (28-29%), LGU (13-14%), AGI (14-19%), and LGI toxicity (8-10%). The meta-analysis showed the 3-, 4-, and 5-year local control rate (LCR) of CIRT for prostate cancer was 98, 97, and 99%; the 3-, 4-, 5-, and 8-year biochemical relapse-free rate (BRF) was 92, 91, 89, and 79%. GRADE assessment results indicated that the certainty of the evidence was very low. Meta-regression results did not show a significant relationship based on the variables studied (P < 0.05). Conclusions:& nbsp;Currently available evidence demonstrated that the efficacy and safety of CIRT and PBT for prostate cancer were similar, and they may significantly improve the OS, LCR, and reduce the incidence of GU and GI toxicity compared with photon radiotherapy. However, the quantity and quality of the available evidence are insufficient. More high-quality controlled studies are needed in the future. |
| WOS关键词 | QUALITY-OF-LIFE ; INTENSITY-MODULATED RADIOTHERAPY ; LONG-TERM OUTCOMES ; BEAM THERAPY ; RADIATION-THERAPY ; ACUTE TOXICITY ; PHASE-II ; METHODOLOGICAL QUALITY ; CONFORMAL RADIOTHERAPY ; 5-YEAR OUTCOMES |
| 资助项目 | National Social Science Fund of China[19ZDA142] ; Key Laboratory of Evidence-Based Medicine and Knowledge Translation Foundation of Gansu Province[GSEBMKT-2020KF01] |
| WOS研究方向 | Oncology |
| 语种 | 英语 |
| 出版者 | FRONTIERS MEDIA SA |
| WOS记录号 | WOS:000713418900001 |
| 资助机构 | National Social Science Fund of China ; Key Laboratory of Evidence-Based Medicine and Knowledge Translation Foundation of Gansu Province |
| 源URL | [http://119.78.100.186/handle/113462/138289]  |
| 专题 | 中国科学院近代物理研究所 |
| 通讯作者 | Wang, Xiaohu; Yang, Kehu |
| 作者单位 | 1.Lanzhou Univ, Sch Clin Med 2, Lanzhou, Peoples R China 2.Lanzhou Univ, Sch Basic Med Sci, Evidence Based Med Ctr, Lanzhou, Peoples R China 3.Lanzhou Univ, Sch Publ Hlth, Evidence Based Social Sci Res Ctr, Lanzhou, Peoples R China 4.Lanzhou Univ, Sch Publ Hlth, Hlth Technol Assessment Ctr, Lanzhou, Peoples R China 5.McMaster Univ, Dept Hlth Res Methods Evidence & Impact, Hamilton, ON, Canada 6.Lanzhou Univ, Sch Clin Med 1, Lanzhou, Peoples R China 7.Lanzhou Heavy Ions Hosp, Lanzhou, Peoples R China 8.Chinese Acad Sci, Inst Modern Phys, Lanzhou, Peoples R China 9.Key Lab Evidence Based Med & Knowledge Translat G, Lanzhou, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Meixuan,Li, Xiuxia,Yao, Liang,et al. Clinical Efficacy and Safety of Proton and Carbon Ion Radiotherapy for Prostate Cancer: A Systematic Review and Meta-Analysis[J]. FRONTIERS IN ONCOLOGY,2021,11:15. |
| APA | Li, Meixuan.,Li, Xiuxia.,Yao, Liang.,Han, Xue.,Yan, Wenlong.,...&Yang, Kehu.(2021).Clinical Efficacy and Safety of Proton and Carbon Ion Radiotherapy for Prostate Cancer: A Systematic Review and Meta-Analysis.FRONTIERS IN ONCOLOGY,11,15. |
| MLA | Li, Meixuan,et al."Clinical Efficacy and Safety of Proton and Carbon Ion Radiotherapy for Prostate Cancer: A Systematic Review and Meta-Analysis".FRONTIERS IN ONCOLOGY 11(2021):15. |
入库方式： OAI收割
来源：近代物理研究所
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