The effects of the Wnt/beta-catenin signaling pathway on apoptosis in HeLa cells induced by carbon ion irradiation
文献类型：期刊论文
| 作者 | Si, Jing1,3,4 ; Zhang, Jinhua1,3,4; Gan, Lu1,3,4; Gu, Menghuan2; Xie, Yi1,3,4; Di, Cuixia1,3,4; Sun, Chao1,3,4; Wang, Fang1,3,4; Yan, Junfang1,3,4; Zhang, Hong1,3,4
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| 刊名 | ONCOLOGY REPORTS
 |
| 出版日期 | 2020-07-01 |
| 卷号 | 44期号:1页码:303-312 |
| 关键词 | C-12(6+) irradiation cervical cancer Wnt/beta-catenin pathway HLY78 radio-sensitivity |
| ISSN号 | 1021-335X |
| DOI | 10.3892/or.2020.7581 |
| 通讯作者 | Zhang, Hong(zhangh@impcas.ac.cn) |
| 英文摘要 | The molecular mechanisms underlying the biological effects of carbon ions are unclear. The aim of this study was to explore the Wnt/beta-catenin pathway in regulating carbon ion (C-12(6+)) radiation-induced cellular toxicity. HLY78 is a Wnt-specific small molecular modulator, whose effects on C-12(6+) radiation-induced damage are mostly unknown. HLY78, in combination with C-12(6+) radiation was investigated on HeLa cell viability, cell cycle progression, DNA damage, and the expression of apoptotic and Wnt-related proteins. C-12(6+) radiation suppressed cell viability in a time-dependent manner, whereas the addition of HLY78 to cells significantly reduced this stress. Moreover, after irradiation with C-12(6+), HeLa cells exhibited increased cell apoptosis, G2/M phase arrest, and a number of gamma-H2AX foci. However, Wnt signaling activation alleviated these effects. Furthermore, when compared with the radiation alone group, supplementation with HLY78 markedly increased the expression of anti-apoptotic and Wnt-related proteins, and significantly decreased the expression of apoptotic proteins. The present results indicated that activation of the Wnt/beta-catenin signaling pathway by HLY78 reduced C-12(6+) radiation-induced HeLa cell dysfunction, suggesting that the Wnt/beta-catenin signaling pathway plays an important role in regulating C-12(6+) radiation-induced cellular toxicity in HeLa cells. |
| WOS关键词 | CERVICAL-CANCER ; ENHANCES RADIOSENSITIVITY ; BETA-CATENIN ; STEM-CELLS ; RADIATION ; PROLIFERATION ; ACTIVATION ; BREAST ; RADIOTHERAPY ; RECOGNITION |
| 资助项目 | National Key R&D Program of China[2018YFE0205100] ; National Natural Science Foundation of China[U1632270] ; National Natural Science Foundation of China[11675234] ; National Natural Science Foundation of China[11875061] ; National Natural Science Foundation of China[31560254] ; Science and Technology Plan Project of Chengguan, Lanzhou[2019RCCX0071] ; Lanzhou Talent Innovation and Entrepreneurship Project[2019-RC-76] |
| WOS研究方向 | Oncology |
| 语种 | 英语 |
| WOS记录号 | WOS:000540620900026 |
| 出版者 | SPANDIDOS PUBL LTD |
| 资助机构 | National Key R&D Program of China ; National Natural Science Foundation of China ; Science and Technology Plan Project of Chengguan, Lanzhou ; Lanzhou Talent Innovation and Entrepreneurship Project |
| 源URL | [http://119.78.100.186/handle/113462/140415]  |
| 专题 | 中国科学院近代物理研究所 |
| 通讯作者 | Zhang, Hong |
| 作者单位 | 1.Chinese Acad Sci, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou 730000, Gansu, Peoples R China 2.Lanzhou Univ, Sch Pharm, Lanzhou 730000, Gansu, Peoples R China 3.Chinese Acad Sci, Inst Modern Phys, 8 Tianshui Middle Rd, Lanzhou 730000, Gansu, Peoples R China 4.Univ Chinese Acad Sci, Coll Life Sci, Beijing 101400, Peoples R China |
| 推荐引用方式 GB/T 7714 | Si, Jing,Zhang, Jinhua,Gan, Lu,et al. The effects of the Wnt/beta-catenin signaling pathway on apoptosis in HeLa cells induced by carbon ion irradiation[J]. ONCOLOGY REPORTS,2020,44(1):303-312. |
| APA | Si, Jing.,Zhang, Jinhua.,Gan, Lu.,Gu, Menghuan.,Xie, Yi.,...&Zhang, Hong.(2020).The effects of the Wnt/beta-catenin signaling pathway on apoptosis in HeLa cells induced by carbon ion irradiation.ONCOLOGY REPORTS,44(1),303-312. |
| MLA | Si, Jing,et al."The effects of the Wnt/beta-catenin signaling pathway on apoptosis in HeLa cells induced by carbon ion irradiation".ONCOLOGY REPORTS 44.1(2020):303-312. |
入库方式： OAI收割
来源：近代物理研究所
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