TANK-binding kinase 1 (TBK1): An emerging therapeutic target for drug discovery
文献类型：期刊论文
| 作者 | Xiang, Shuang2; Song, Shukai2; Tang, Haotian3; Smaill, Jeff B.1; Wang, Aiqun4; Xie, Hua3 ; Lu, Xiaoyun2
|
| 刊名 | DRUG DISCOVERY TODAY
 |
| 出版日期 | 2021-10-01 |
| 卷号 | 26期号:10页码:2445-2455 |
| 关键词 | Antibiotic resistance Computational biology Databases In silico tools |
| ISSN号 | 1359-6446 |
| DOI | 10.1016/j.drudis.2021.05.016 |
| 通讯作者 | Wang, Aiqun(wangaiqunhhyy@163.com) ; Xie, Hua(hxie@simm.ac.cn) ; Lu, Xiaoyun(luxy2016@jnu.edu.cn) |
| 英文摘要 | Dysregulation of TANK-binding kinase 1 (TBK1) homeostasis leads to the occurrence and progression of many diseases, such as inflammation, autoimmune diseases, metabolic diseases, and cancer. Therefore, there is a need to develop TBK1 inhibitors as therapeutic agents. In this review, we highlight the diverse biological functions of TBK1 and summarize the promising small-molecule inhibitors of TBK1 that have the potential to be developed as therapeutic candidates. |
| WOS关键词 | INNATE IMMUNE ; IKK-EPSILON ; MOLECULAR-MECHANISMS ; ANTIVIRAL RESPONSE ; ACTIVATION ; AUTOPHAGY ; INHIBITION ; CANCER ; PHOSPHORYLATION ; INFLAMMATION |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000709771700026 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/298338]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Wang, Aiqun; Xie, Hua; Lu, Xiaoyun |
| 作者单位 | 1.Univ Auckland, Sch Med Sci, Auckland Canc Soc Res Ctr, Private Bag 92019, Auckland 1142, New Zealand 2.Jinan Univ, 601 Huangpu Ave West, Guangzhou 510632, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Div Antitumor Pharmacol, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China 4.Jinan Univ, Guangzhou Red Cross Hosp, Dept Anesthesiol, Guangzhou 510220, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xiang, Shuang,Song, Shukai,Tang, Haotian,et al. TANK-binding kinase 1 (TBK1): An emerging therapeutic target for drug discovery[J]. DRUG DISCOVERY TODAY,2021,26(10):2445-2455. |
| APA | Xiang, Shuang.,Song, Shukai.,Tang, Haotian.,Smaill, Jeff B..,Wang, Aiqun.,...&Lu, Xiaoyun.(2021).TANK-binding kinase 1 (TBK1): An emerging therapeutic target for drug discovery.DRUG DISCOVERY TODAY,26(10),2445-2455. |
| MLA | Xiang, Shuang,et al."TANK-binding kinase 1 (TBK1): An emerging therapeutic target for drug discovery".DRUG DISCOVERY TODAY 26.10(2021):2445-2455. |
入库方式： OAI收割
来源：上海药物研究所
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