I-2-induced cascade cyclization and dearomatization of indoles for the highly efficient synthesis of iodinated and vinylic spiroindolenines
文献类型：期刊论文
| 作者 | Wei, Xiaohui1,2; Liang, Xuewu2; Li, Yazhou2; Liu, Qi2; Liu, Xuyi2; Zhou, Yu2 ; Liu, Hong1,2
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| 刊名 | GREEN CHEMISTRY
 |
| 出版日期 | 2021-11-16 |
| 卷号 | 23期号:22页码:9165-9171 |
| ISSN号 | 1463-9262 |
| DOI | 10.1039/d1gc02713a |
| 通讯作者 | Zhou, Yu(zhouyu@simm.ac.cn) ; Liu, Hong(hliu@simm.ac.cn) |
| 英文摘要 | The spiroindolenine framework is a privileged heterocyclic motif and is widely present in numerous indole alkaloids. Herein, we develop a metal-free and environmentally friendly approach for the intramolecular cascade cyclization and dearomatization of indole derivatives to selectively afford iodinated and vinylic spiroindolenines by a substrate-controlled strategy. Simple operation, mild conditions, and high yield make this strategy a green and attractive pathway to construct functionalizable spiroindolenine scaffolds, which could be converted into diverse useful spiroindolenine derivatives. |
| WOS关键词 | ASYMMETRIC ALLYLIC DEAROMATIZATION ; MOLECULAR-IODINE ; ELECTROPHILIC CYCLIZATION ; GARDNERIA ALKALOIDS ; GOLD ; IODOCYCLIZATION ; NANOPARTICLES ; ALKYLATION |
| 资助项目 | National Natural Science Foundation of China[21907102] ; National Natural Science Foundation of China[82130105] ; National Natural Science Foundation of China[82121005] |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000714407400001 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/298790]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Zhou, Yu; Liu, Hong |
| 作者单位 | 1.China Pharmaceut Univ, 639 Longmian Ave, Nanjing 211198, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wei, Xiaohui,Liang, Xuewu,Li, Yazhou,et al. I-2-induced cascade cyclization and dearomatization of indoles for the highly efficient synthesis of iodinated and vinylic spiroindolenines[J]. GREEN CHEMISTRY,2021,23(22):9165-9171. |
| APA | Wei, Xiaohui.,Liang, Xuewu.,Li, Yazhou.,Liu, Qi.,Liu, Xuyi.,...&Liu, Hong.(2021).I-2-induced cascade cyclization and dearomatization of indoles for the highly efficient synthesis of iodinated and vinylic spiroindolenines.GREEN CHEMISTRY,23(22),9165-9171. |
| MLA | Wei, Xiaohui,et al."I-2-induced cascade cyclization and dearomatization of indoles for the highly efficient synthesis of iodinated and vinylic spiroindolenines".GREEN CHEMISTRY 23.22(2021):9165-9171. |
入库方式： OAI收割
来源：上海药物研究所
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