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Sulfoximines Assisted Rh(III)-Catalyzed C-H Activation/Annulation Cascade to Synthesize Highly Fused Indeno-1,2-benzothiazines

文献类型：期刊论文

作者Li, Jian1,2; Li, Hui1,2; Fang, Daqing2; Liu, Lingjun2; Han, Xu2; Sun, Jina2,3; Li, Chunpu2; Zhou, Yu2,3; Ye, Deju4; Liu, Hong1,2,3
刊名JOURNAL OF ORGANIC CHEMISTRY
出版日期2021-11-05
卷号86期号:21页码:15217-15227
ISSN号0022-3263
DOI10.1021/acs.joc.1c01820
通讯作者Ye, Deju(dejuye@nju.edu.cn) ; Liu, Hong(hliu@simm.ac.cn)
英文摘要A facile access to highly fused tetracyclic indeno-1,2-benzothiazines has been established via a Rh(III)-catalyzed C-H bond activation and intramolecular annulation cascade between sulfoximides and all-carbon diazo indandiones. This strategy is characterized by the fact that the diazo coupling partners do not require preactivation, along with its high efficiency, broad substrate generality, and facile transformation. Particularly, the highly conjugated tetracyclic products demonstrate good optical properties and can easily enter cells to emit bright fluorescence for live cell imaging.
WOS关键词CATALYZED OXIDATIVE ANNULATION ; DIAZO-COMPOUNDS ; BOND FORMATION ; CARBENOID FUNCTIONALIZATION ; ACTIVATION ; ACCESS ; 1,2-BENZOTHIAZINES ; BENZOTHIAZINES ; BENZYLAMINES ; DERIVATIVES
资助项目National Natural Science Foundation of China[21632008] ; National Natural Science Foundation of China[21877118] ; National Natural Science Foundation of China[81620108027] ; National Natural Science Foundation of China[91953108] ; Science Technology Commission of Shanghai Municipality[18JC1411304] ; Science Technology Commission of Shanghai Municipality[18431907100] ; SASIBS Scholarship Program ; Youth Innovation Promotion Association CAS
WOS研究方向Chemistry
语种英语
出版者AMER CHEMICAL SOC
WOS记录号WOS:000716778300076
源URL[http://119.78.100.183/handle/2S10ELR8/299042]  
专题新药研究国家重点实验室
通讯作者Ye, Deju; Liu, Hong
作者单位1.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Nanjing Univ, Sch Chem & Chem Engn, State Key Lab Analyt Chem Life Sci, Nanjing 210023, Peoples R China
推荐引用方式
GB/T 7714		 Li, Jian,Li, Hui,Fang, Daqing,et al. Sulfoximines Assisted Rh(III)-Catalyzed C-H Activation/Annulation Cascade to Synthesize Highly Fused Indeno-1,2-benzothiazines[J]. JOURNAL OF ORGANIC CHEMISTRY,2021,86(21):15217-15227.
APA Li, Jian.,Li, Hui.,Fang, Daqing.,Liu, Lingjun.,Han, Xu.,...&Liu, Hong.(2021).Sulfoximines Assisted Rh(III)-Catalyzed C-H Activation/Annulation Cascade to Synthesize Highly Fused Indeno-1,2-benzothiazines.JOURNAL OF ORGANIC CHEMISTRY,86(21),15217-15227.
MLA Li, Jian,et al."Sulfoximines Assisted Rh(III)-Catalyzed C-H Activation/Annulation Cascade to Synthesize Highly Fused Indeno-1,2-benzothiazines".JOURNAL OF ORGANIC CHEMISTRY 86.21(2021):15217-15227.

入库方式： OAI收割

来源：上海药物研究所

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