Synthesis and antiviral activity of 2 '-deoxy-6 '-substituted carbocyclic nucleosides
文献类型：期刊论文
| 作者 | Xue, Haitao1,2; Guo, Shuang1,2; Hu, Tianwen2,3; Wei, Daibao2,3; Xie, Yuanchao1; Shen, Jingshan1,2
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| 刊名 | CHEMICAL BIOLOGY & DRUG DESIGN
 |
| 出版日期 | 2021-12-18 |
| 页码 | 12 |
| 关键词 | 2 '-deoxy carbocyclic nucleoside antiviral activity hepatitis B virus Mitsunobu reaction |
| ISSN号 | 1747-0277 |
| DOI | 10.1111/cbdd.13998 |
| 通讯作者 | Xie, Yuanchao(xieyuanchao@simm.ac.cn) |
| 英文摘要 | A series of 2'-deoxy carbocyclic nucleosides characterized by various 6'-substitutions were synthesized and evaluated for their antiviral activities against three viruses, including hepatitis B virus (HBV), hepatitis C virus, and influenza virus. The in vitro antiviral assays indicated that these nucleosides only showed inhibitory activities against HBV, and the substituted groups at the 6' position significantly affected the activity. Among them, the guanosine analog 2b bearing a 6'-alpha-hydroxyl methyl group was the most potent compound with an EC50 value of 80 nM. The present study provided useful information for the discovery of antiviral carbocyclic nucleosides. |
| WOS关键词 | POTENT ; ENTECAVIR ; ANTITUMOR ; ANALOG |
| 资助项目 | Shanghai Science and Technology Committee in China[21S11903100] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000731280700001 |
| 出版者 | WILEY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/299175]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Xie, Yuanchao |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, State Key Lab Basis Xinjiang Indigenous Med Plant, Urumqi, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xue, Haitao,Guo, Shuang,Hu, Tianwen,et al. Synthesis and antiviral activity of 2 '-deoxy-6 '-substituted carbocyclic nucleosides[J]. CHEMICAL BIOLOGY & DRUG DESIGN,2021:12. |
| APA | Xue, Haitao,Guo, Shuang,Hu, Tianwen,Wei, Daibao,Xie, Yuanchao,&Shen, Jingshan.(2021).Synthesis and antiviral activity of 2 '-deoxy-6 '-substituted carbocyclic nucleosides.CHEMICAL BIOLOGY & DRUG DESIGN,12. |
| MLA | Xue, Haitao,et al."Synthesis and antiviral activity of 2 '-deoxy-6 '-substituted carbocyclic nucleosides".CHEMICAL BIOLOGY & DRUG DESIGN (2021):12. |
入库方式： OAI收割
来源：上海药物研究所
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