Detecting CD20-Rituximab specific interactions on lymphoma cells using atomic force microscopy
文献类型：期刊论文
| 作者 | Li M(李密) ; Liu LQ(刘连庆); Wang YC(王越超); Dong ZL(董再励); Li GY(李广勇); Xiao XB(肖秀斌); Zhang WJ(张伟京)
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| 刊名 | Science China(Life Sciences)
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| 出版日期 | 2010 |
| 卷号 | 53期号:10页码:1189–1195 |
| 关键词 | Atomic Force Microscopy Single-molecule Force Spectroscopy Cd20 Antigen Rituximab |
| ISSN号 | 1674-7305 |
| 产权排序 | 1 |
| 英文摘要 | Elucidating the underlying mechanisms of cell physiology is currently an important research topic in life sciences. Atomic force microscopy methods can be used to investigate these molecular mechanisms. In this study, single-molecule force spectroscopy was used to explore the specific recognition between the CD20 antigen and anti-CD20 antibody Rituximab on B lymphoma cells under near-physiological conditions. The CD20-Rituximab specific binding force was measured through tip functionalization. |
| WOS关键词 | Monoclonal-antibody Therapy ; Single-molecule ; Living Cells ; Recognition Events ; Cancer ; Resolution ; Receptor ; Surface ; Localization ; Spectroscopy |
| WOS研究方向 | Life Sciences & Biomedicine - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000283120000005 |
| 资助机构 | supported by the National Natural Science Foundation of China (Grant Nos. 60904095 and 60635040) ; the National High Technology |
| 公开日期 | 2012-05-29 |
| 源URL | [http://ir.sia.cn/handle/173321/7339]  |
| 专题 | 沈阳自动化研究所_机器人学研究室 |
| 通讯作者 | Liu LQ(刘连庆); Wang YC(王越超) |
| 作者单位 | 1.Graduate University of Chinese Academy of Sciences, Beijing 100049, China 2.Department of Lymphoma Affiliated Hospital of Military Medical Academy of Sciences, Beijing 100071, China 3.State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China 4.State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang 110016, China 5.Department of Electrical and Computer Engineering, Michigan State University, East Lansing 48824, USA 6.Department of Electrical and Computer Engineering, University of Pittsburgh, Pittsburgh 15261, USA |
| 推荐引用方式 GB/T 7714 | Li M,Liu LQ,Wang YC,et al. Detecting CD20-Rituximab specific interactions on lymphoma cells using atomic force microscopy[J]. Science China(Life Sciences),2010,53(10):1189–1195. |
| APA | Li M.,Liu LQ.,Wang YC.,Dong ZL.,Li GY.,...&Zhang WJ.(2010).Detecting CD20-Rituximab specific interactions on lymphoma cells using atomic force microscopy.Science China(Life Sciences),53(10),1189–1195. |
| MLA | Li M,et al."Detecting CD20-Rituximab specific interactions on lymphoma cells using atomic force microscopy".Science China(Life Sciences) 53.10(2010):1189–1195. |
入库方式： OAI收割
来源：沈阳自动化研究所
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