An experimental study on imaging Burkitt's lymphoma cells by atomic force microscope
文献类型：会议论文
| 作者 | Li M(李密) ; Liu LQ(刘连庆); Wang YC(王越超); Dong ZL(董再励); Li GY(李广勇); Xiao XB(肖秀斌); Yuan, Shunzong; Zhang WJ(张伟京)
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| 出版日期 | 2010 |
| 会议日期 | January 20-23, 2010 |
| 会议地点 | Xiamen, China |
| 关键词 | Cell Membranes Liquids Microscopes Morphology Oncology Surface Structure |
| 页码 | 262-266 |
| 英文摘要 | Burkitt's lymphoma (BL) is a highly aggressive malignant tumor with high morbidity rate in children. Patients have different responses to the same therapy due to the molecular heterogeneity. Detailed observation of the surface structure of BL cells to locate the specific receptors (CD20) on the cell surface and measure the binding force between the CD20s and their cognate ligands (Rituximab) may give people a further understanding to BL cell's intrinsic properties and provide complementary approaches for the next generation of drug research and development. In this paper, we give an experimental study on how to obtain the morphology images of the BL cells both in air and liquid with atomic force microscope (AFM).The detailed procedures such as sample preparation of BL cells, parameter setting of AFM and so on, are presented, and the experimental results illustrate that the morphology image of the BL cell can be obtained in air or liquid respectively by using AFM. ©2010 IEEE. |
| 产权排序 | 1 |
| 会议录 | 2010 IEEE 5th International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2010
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| 会议录出版者 | IEEE Computer Society |
| 会议录出版地 | Piscataway, NJ |
| 语种 | 英语 |
| ISBN号 | 978-1-4244-6543-9 |
| 源URL | [http://ir.sia.cn/handle/173321/8566]  |
| 专题 | 沈阳自动化研究所_机器人学研究室 |
| 通讯作者 | Li M(李密) |
| 作者单位 | 1.Department of Lyphoma, Military Medical Academy of Sciences, Beijing, 100071, China 2.State Key Laboratory of Robotics, Shenyang Institute of Automation, CAS, Shenyang, 110016, China 3.Department of Electrical and Computer Engineering, Michigan State University, East Lansing, MI 48824, United States 4.Department of Electrical and Computer Engineering, University of Pittsburgh, Pittsburgh, PA, 15261, United States 5.Graduate University of Chinese Academy of Sciences, Beijing 100001, China |
| 推荐引用方式 GB/T 7714 | Li M,Liu LQ,Wang YC,et al. An experimental study on imaging Burkitt's lymphoma cells by atomic force microscope[C]. 见:. Xiamen, China. January 20-23, 2010. |
入库方式： OAI收割
来源：沈阳自动化研究所
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