Stiffness measurement of Burkitt's lymphoma cells with atomic force microscopy
文献类型：会议论文
| 作者 | Li M(李密) ; Liu LQ(刘连庆); Wang YC(王越超); Dong ZL(董再励); Xiao XB(肖秀斌); Zhang WJ(张伟京)
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| 出版日期 | 2010 |
| 会议日期 | June 18-20, 2010 |
| 会议地点 | Chengdu, China |
| 关键词 | Aldehydes Amino Acids Atomic Force Microscopy Atoms Bioinformatics Biomaterials Diagnosis Elastic Moduli Elasticity Mechanical Properties Oncology Stiffness Substrates |
| 英文摘要 | Cell stiffness is closely related to human health and diseases. Measuring the mechanical property of individual cells may help us to understand the mechanism of diseases at cell level and provide new methods for disease diagnosis and personalized treatment. In this paper, the poly-1-lysine was used to immobilize Burkitt's lymphoma (BL) cells onto the glass substrate for being imaged in fluid by atomic force microscopy (AFM). In nearphysiological environment, with the use of AFM, the high resolution morphology image of BL cells was obtained and the mechanical property of BL cells was measured. The detailed processes of the sample preparation and computing the Young's modulus of BL cells from force curves were presented. The experimental result indicated that the Young's modulus of BL cells fixed by glutaraldehyde was about 1MPa. These results may provide useful knowledge for understanding the mechanism of lymphoma and the application of AFM to cancer diagnosis. |
| 源文献作者 | IEEE Engineering in Medicine and Biology Society; Sichuan University; Wuhan University |
| 产权排序 | 1 |
| 会议录 | 2010 4th International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2010
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| 会议录出版者 | IEEE Computer Society |
| 会议录出版地 | Piscataway, NJ |
| 语种 | 英语 |
| ISBN号 | 978-1-4244-4713-8 |
| WOS记录号 | WOS:000397260202108 |
| 源URL | [http://ir.sia.cn/handle/173321/8886]  |
| 专题 | 沈阳自动化研究所_机器人学研究室 |
| 通讯作者 | Li M(李密); Liu LQ(刘连庆) |
| 作者单位 | 1.Graduate School of Chinese Academy of Sciences, Beijing 100001, China 2.Department of Lyphoma, Affiliated Hospital of Military Medical Academy of Sciences, Beijing, 100071, China 3.Department of Electrical and Computer Engineering, Michigan State University, East Lansing, MI 48824, United States 4.State Key Laboratory of Robotics, Shenyang Institute of Automation, CAS, Shenyang, 110016, China |
| 推荐引用方式 GB/T 7714 | Li M,Liu LQ,Wang YC,et al. Stiffness measurement of Burkitt's lymphoma cells with atomic force microscopy[C]. 见:. Chengdu, China. June 18-20, 2010. |
入库方式： OAI收割
来源：沈阳自动化研究所
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