Investigation of protein-protein interactions in cancer targeted therapy using nanorobots
文献类型：专著章节
| 作者 | Li M(李密) ; Liu LQ(刘连庆); Wang YC(王越超); Dong ZL(董再励); Xiao XB(肖秀斌); Zhang WJ(张伟京)
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| 发表日期 | 2013 |
| 其他责任者 | Yi Guo |
| 出处 | Selected Topics in Micro/Nano-robotics for Biomedical Applications |
| 出版地 | Berlin |
| ISBN号 | 978-1-4419-8410-4 |
| 出版者 | Springer-Verlag |
| 页码 | 125-158 |
| 产权排序 | 1 |
| 英文摘要 | This chapter describes the applications of nanorobots in investigating the mechanisms of rituximab’s different efficacies in the targeted therapy of B-cell lymphomas at the individual cellular/molecular level. The chapter begins with an introduction to the new challenges in the field of cancer targeted therapy, taking rituximab targeted therapy in B-cell lymphoma for example. The following section presents a detailed description of the principles and methods of single-molecule techniques based on nanorobots. Next, it presents the microfabricated pillar-based cell immobilization method and discusses how to obtain the topography of individual living mammalian suspension cells based on this immobilization method. Next, it presents how to use nanorobot indentation experiments to measure the mechanical properties of individual cells. Next, the processes of using nanorobots to measure the individual molecular binding forces and three-dimensionally visualize the distribution of CD20 proteins on the lymphoma cell surface with the probe functionalization technology are detailed. The remainder of the chapter presents the specific binding force measurements on different lymphoma patients’ cells and discusses its relation to rituximab’s variable efficacies. The intent of this chapter is to provide the practical knowledge to begin the investigations on individual cells and molecules with nanorobots. |
| 语种 | 英语 |
| 源URL | [http://ir.sia.cn/handle/173321/10252]  |
| 专题 | 沈阳自动化研究所_机器人学研究室 |
| 通讯作者 | Liu LQ(刘连庆); Wang YC(王越超) |
| 作者单位 | 1.Department of Electrical and Computer Engineering, Michigan State University, East Lansing, United States 2.State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang, China 3.Department of Lymphoma, Affiliated Hospital of Military Medical Academy of Sciences, Beijing, China |
| 推荐引用方式 GB/T 7714 | Li M,Liu LQ,Wang YC,et al. Investigation of protein-protein interactions in cancer targeted therapy using nanorobots. Berlin:Springer-Verlag,2013:125-158. |
入库方式： OAI收割
来源：沈阳自动化研究所
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