Physical Forces Influence the Self-organization of the Leader Cell Formation During Collective Cell Migration
文献类型：会议论文
| 作者 | Pan MY(潘梦云)1,2,3; Yang YL(杨永良)2,3; Liu LQ(刘连庆)2,3
|
| 出版日期 | 2021 |
| 会议日期 | April 25-29, 2021 |
| 会议地点 | Xiamen, China |
| 页码 | 1923-1926 |
| 英文摘要 | Many dynamic physiological processes, including embryo development and wound healing, involve collective cell migration. During this process, leader cells emerge in self-organization manner to guide other cells migration. The mechanisms of their formation, however, are not clear. We hypothesized that the physical forces among cells, and between cell and substrate influence the formation of leader cells. Here, we presented a computational model of cell monolayer migration based on the Glazier-Graner-Hogeweg (GGH) model. Our results indicated that the adhesion forces among cells and the cell-substrate adhesion forces regulate the formation of leader cells. Increasing cellular mobility also affected the characters of leader cells. In summary, our results provided evidence for that physical forces among cells and between cell and substrate, along with mobility of individual cells, affect the self-organization process of leader cell formation during collective cell migration. |
| 源文献作者 | IEEE, IEEE Nanotechnol Council, Peking Univ, Univ Amoiensis, UESTC, ICANX |
| 产权排序 | 1 |
| 会议录 | Proceedings of the 16th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2021
 |
| 会议录出版者 | IEEE |
| 会议录出版地 | New York |
| 语种 | 英语 |
| ISSN号 | 2474-3747 |
| ISBN号 | 978-0-7381-2429-2 |
| WOS记录号 | WOS:000693407600229 |
| 源URL | [http://ir.sia.cn/handle/173321/29657]  |
| 专题 | 沈阳自动化研究所_机器人学研究室 |
| 通讯作者 | Pan MY(潘梦云) |
| 作者单位 | 1.University of Chinese Academy of Sciences, Beijing 100049, China 2.Institutes for Robotics and Intelligent Manufacturing, Chinese Academy of Sciences, Shenyang 110169, China 3.State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang 110016, China |
| 推荐引用方式 GB/T 7714 | Pan MY,Yang YL,Liu LQ. Physical Forces Influence the Self-organization of the Leader Cell Formation During Collective Cell Migration[C]. 见:. Xiamen, China. April 25-29, 2021. |
入库方式： OAI收割
来源：沈阳自动化研究所
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