A Pharmacodynamic Evaluation Method Based on Optogenetics and Graphene FETs
文献类型：会议论文
| 作者 | Yang J(杨佳)2,3,4 ; Zu LP(祖立鹏)2,3,4; Dang D(党丹)1; Li MY(李梦月)2,3,4; Wang WX(王文学)3,4
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| 出版日期 | 2021 |
| 会议日期 | July 27-31, 2021 |
| 会议地点 | Jiaxing, China |
| 页码 | 408-413 |
| 英文摘要 | Screening of new anticancer drugs and personalized medicine are of great significance for improving clinical cancer treatment and prolonging the lifespan of people diagnosed with cancers. Cell-based drug testing approaches that rely on complicated electrophysiological measurements or chemical activators and reporters are usually invasive and low throughput, therefore it is very imperative to develop an easy handling and efficient method to evaluate the efficacy of anticancer drugs. In this study, we present a simple and efficient method for pharmacodynamic evaluation based on optogenetics and graphene-based field-effect transistors (GFETs). This method involves the fusion of optogenetically engineered cancer cells and a GFET, in which the photoinduced bioelectricity of cells regulates the transistor output current. The experimental results showed that the light-dependent increment in the transistor output current of GFET falls dramatically upon the action of drugs, indicating the GFET with engineered cells can be used to evaluate drug efficacy. In addition, the drug efficacy evaluation with GFET is affected by the drain-source voltage, and the experimental results showed that drug efficacy can be better characterized at an appropriate drain-source voltage. These results demonstrated that the proposed method is effective and efficient for qualitative evaluation of drug efficacy. This method based on optogenetics and GFET is of significant value in drug screening and personalized therapies. © 2021 IEEE. |
| 源文献作者 | IEEE Robotics and Automation Society ; Shenyang Institute of Automation CAS ; Shenzhen Academy of Robotics |
| 产权排序 | 1 |
| 会议录 | 2021 IEEE 11th International Conference on CYBER Technology in Automation, Control, and Intelligent Systems, CYBER 2021
 |
| 会议录出版者 | IEEE |
| 会议录出版地 | New York |
| 语种 | 英语 |
| ISSN号 | 2642-6633 |
| ISBN号 | 978-1-6654-2527-8 |
| 源URL | [http://ir.sia.cn/handle/173321/29933]  |
| 专题 | 沈阳自动化研究所_机器人学研究室 |
| 通讯作者 | Wang WX(王文学) |
| 作者单位 | 1.Faculty of Medical Devices, Shenyang Pharmaceutical University, Shenyang 110016, China 2.University of Chinese Academy of Sciences, Beijing 100049, China 3.State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang 110016, China 4.Institute for Robotics and Intelligent Manufacturing, Shenyang 110016, China |
| 推荐引用方式 GB/T 7714 | Yang J,Zu LP,Dang D,et al. A Pharmacodynamic Evaluation Method Based on Optogenetics and Graphene FETs[C]. 见:. Jiaxing, China. July 27-31, 2021. |
入库方式： OAI收割
来源：沈阳自动化研究所
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