To effectively minimize the launch mass and physical size constrained by the launch vehicles, the space experiment facilities are compactly designed using thin frame and shell structures to house high-precision and delicate instruments and experiment apparatuses, which are typical shock sensitive. When the construction of these facilities is completed, they need to be transported to the launch site to be integrated into the launch vehicles. Due to uneven and sometime rough road terrains, poor shock suspension system of the transportation vehicles, and high travel speed, the vibration excited between the road surfaces and vehicle wheels will be directly transmitted to the scientific experiment facilities via the vehicle bodies, which may potentially damage the delicate instruments or deviate the calibrations. Therefore, a vibration isolation system is needed to prevent the experiment facilities from being affected by the vibrations and shocks during the transportation. This paper will present the design of an effective vibration/shock isolation system for such applications. A six degree-of-freedom dynamic model of the vibration isolation system is established using ADAMS, and the vibration isolation efficiency and shock responses in Cartesian space are calculated. The simulation results show that the vibration isolation system is effective to attenuate high frequency vibrations and shocks in all three axes of the Cartesian space.