Applanmerotic acids A and B, two meroterpenoid dimers with an unprecedented polycyclic skeleton from Ganoderma applanatum that inhibit formyl peptide receptor 2
文献类型：期刊论文
| 作者 | Peng,Xingrong; Su,Haiguo; Wang,Huirong; Hu,Guilin; Hu,Kun ; Zhou,Lin; Qiu,Minghua
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| 刊名 | ORGANIC CHEMISTRY FRONTIERS
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| 出版日期 | 2021 |
| 卷号 | 8期号:13页码:3381-3389 |
| ISSN号 | 2052-4129 |
| DOI | 10.1039/d1qo00294e |
| 英文摘要 | Two unprecedented Ganoderma meroterpenoid dimers, applanmerotic acids A and B (1 and 2), were isolated from the fruiting bodies of Ganoderma applanatum. Their structures including stereostructures were established by spectroscopic analysis and the quantum chemical calculation (calculated C-13 NMR and electronic circular dichroism) method. Compound 1 was a pair of enantiomers and compound 2 represents the first example of a dimeric meroterpenoid with a 2-oxo-spiro[furo[3,2-b]benzofuran-3,2 '-naphthalene] core. Their plausible biogenetic pathway was proposed, from which their key polycyclic cores were formed through an intermolecular Diels-Alder reaction. Compounds 1 and 2 showed anti-inflammatory activities with IC50 values of 14.5 and 20.9 mu M, respectively, by inhibiting the activation of FPR2 and the further competitive binding assay and molecular docking study indicated their action mechanism. |
| WOS记录号 | WOS:000644864900001 |
| 源URL | [http://ir.kib.ac.cn/handle/151853/73345]  |
| 专题 | 中国科学院昆明植物研究所 |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Southern Univ Sci & Technol, Dept Biol, Shenzhen, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Peng,Xingrong,Su,Haiguo,Wang,Huirong,et al. Applanmerotic acids A and B, two meroterpenoid dimers with an unprecedented polycyclic skeleton from Ganoderma applanatum that inhibit formyl peptide receptor 2[J]. ORGANIC CHEMISTRY FRONTIERS,2021,8(13):3381-3389. |
| APA | Peng,Xingrong.,Su,Haiguo.,Wang,Huirong.,Hu,Guilin.,Hu,Kun.,...&Qiu,Minghua.(2021).Applanmerotic acids A and B, two meroterpenoid dimers with an unprecedented polycyclic skeleton from Ganoderma applanatum that inhibit formyl peptide receptor 2.ORGANIC CHEMISTRY FRONTIERS,8(13),3381-3389. |
| MLA | Peng,Xingrong,et al."Applanmerotic acids A and B, two meroterpenoid dimers with an unprecedented polycyclic skeleton from Ganoderma applanatum that inhibit formyl peptide receptor 2".ORGANIC CHEMISTRY FRONTIERS 8.13(2021):3381-3389. |
入库方式： OAI收割
来源：昆明植物研究所
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