New synthetic adriamycin-incorporated chitosan nanoparticles with enhanced antioxidant, antitumor activities and pH-sensitive drug release
文献类型：期刊论文
| 作者 | Mi, Yingqi3,4,5; Chen, Yuan2; Gu, Guodong1; Miao, Qin3,4,5; Tan, Wenqiang4,5 ; Li, Qing4,5; Guo, Zhanyong3,4,5
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| 刊名 | CARBOHYDRATE POLYMERS
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| 出版日期 | 2021-12-01 |
| 卷号 | 273页码:11 |
| 关键词 | Chitosan Drug release Cell viability Antitumor activity |
| ISSN号 | 0144-8617 |
| DOI | 10.1016/j.carbpol.2021.118623 |
| 通讯作者 | Guo, Zhanyong(zhanyongguo@hotmail.com) |
| 英文摘要 | In this paper, adriamycin-incorporated chitosan nanoparticles were synthesized by ionic gelation using negatively charged carboxymethyl chitosan and positively charged 2-hydroxypropyltrimethyl ammonium chloride chitosan. The method was efficient to obtain nanoparticles with low polydispersity index and small hydrodynamic diameter. And high zeta potential value indicated that nanoparticles had good stability. The adriamycin release of nanoparticles represented a significant response to pH, with the fastest release in phosphate buffer solution at pH 6.8. Meanwhile, the antioxidant efficiency of nanoparticles was assayed, and nanoparticles represented significant enhancement in radicals scavenging activity. The assay of cell viability by CCK-8 test exhibited that nanoparticles led to statistically significant decrease in cell viability for four kinds of cancer cells (HEPG-2, A549, MCF-7, and BGC-823). It was indicated that the nanoparticles with enhanced biological activity, reduced cytotoxicity, and pH-sensitive release could be served as potential drug carrier in drug delivery system. |
| WOS关键词 | CARBOXYMETHYL CHITOSAN ; CYTOTOXICITY ; DELIVERY ; CHLORIDE ; SULFATE |
| WOS研究方向 | Chemistry ; Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000704406600003 |
| 资助机构 | National Key R&D Program of China ; Youth Innovation Promotion Association CAS ; Natural Science Foundation of Shangdong Province of China ; Natural Science Foundation of Shandong Province Science and Technology Development Plan |
| 源URL | [http://ir.yic.ac.cn/handle/133337/30781]  |
| 专题 | 海岸带生物学与生物资源利用重点实验室 烟台海岸带研究所_海岸带生物学与生物资源利用所重点实验室 海岸带生物资源高效利用研究与发展中心 |
| 通讯作者 | Guo, Zhanyong |
| 作者单位 | 1.Alliance Pharma Inc, 17 Lee Blvd, Malvern, PA 19355 USA 2.Ludong Univ, Sch Chem & Mat Sci, Yantai 264025, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Ctr Ocean Mega Sci, 7 Nanhai Rd, Qingdao 266071, Peoples R China 5.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China |
| 推荐引用方式 GB/T 7714 | Mi, Yingqi,Chen, Yuan,Gu, Guodong,et al. New synthetic adriamycin-incorporated chitosan nanoparticles with enhanced antioxidant, antitumor activities and pH-sensitive drug release[J]. CARBOHYDRATE POLYMERS,2021,273:11. |
| APA | Mi, Yingqi.,Chen, Yuan.,Gu, Guodong.,Miao, Qin.,Tan, Wenqiang.,...&Guo, Zhanyong.(2021).New synthetic adriamycin-incorporated chitosan nanoparticles with enhanced antioxidant, antitumor activities and pH-sensitive drug release.CARBOHYDRATE POLYMERS,273,11. |
| MLA | Mi, Yingqi,et al."New synthetic adriamycin-incorporated chitosan nanoparticles with enhanced antioxidant, antitumor activities and pH-sensitive drug release".CARBOHYDRATE POLYMERS 273(2021):11. |
入库方式： OAI收割
来源：烟台海岸带研究所
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