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Simultaneous Quantification of Four Compounds in Rat Plasma by HPLC-MS/MS and Its Application to Pharmacokinetic Study after Oral Administration of Pomegranate Flowers

文献类型：期刊论文

作者Yisimayili, Zainaipuguli1,2,3; Tian, Qiang3; Xie, Yang3; Hu, Pei3; Abdulla, Rahima2; Wu, Tao1,2; Sun, Zhaolin3; Chen, Mingcang3; Aisa, Haji Akber1,2; Huang, Chenggang1,3
刊名JOURNAL OF CHROMATOGRAPHIC SCIENCE
出版日期2021-06-23
页码9
ISSN号0021-9665
DOI10.1093/chromsci/bmab077
通讯作者Aisa, Haji Akber(haji@ms.xjb.ac.cn) ; Huang, Chenggang(cghsimm@126.com)
英文摘要Pomegranate flowers (PFs) were reported to possess various biological activities such as antidiabetic, anti-inflammatory and hepatoprotective activities, and using to treat diabetes. Although chemical constituents and pharmacological activities of PFs have been studied, unfortunately, there was no report on the pharmacokinetic profile of PFs in vivo. In this study, a selective high-performance liquid chromatography triple quadrupole tandem mass spectrometry (HPLC-QQQ-MS/MS) method was developed and validated for simultaneous quantification of four compounds (corilagin, ellagic acid, gallic acid and brevifolincarboxylic acid) in rat plasma after oral administration of PFs. The good linearity concentration ranges for the four analytes were from 2.5 to 3000 ng/mL with coefficient value R-2 > 0.99 in calibration curves. The intra- and inter-day accuracy of the four analytes was in the range of 85.33-102.50%, with relative standard deviation (RSD) of <14.81%. The stability results showed that accuracy of the four analytes was in the range of 81.88-104.74%, with RSD of in vivo mechanisms of PFs and may facilitate its further development as therapeutic agent.
WOS关键词ANTIOXIDANT ; LIVER ; VALIDATION ; CORILAGIN ; EXTRACT ; ACID
资助项目Major science and technology projects in Xinjiang Uighur Autonomous Region[2016A03005-3] ; Science and Technology Service Network Plan of Chinese Academy of Sciences[KFJ-STS-QYZD-066]
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
语种英语
WOS记录号WOS:000755809400001
出版者OXFORD UNIV PRESS INC
源URL[http://119.78.100.183/handle/2S10ELR8/300421]  
专题中国科学院上海药物研究所
通讯作者Aisa, Haji Akber; Huang, Chenggang
作者单位1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
2.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Chem Arid Zone, Urumqi 830011, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Yisimayili, Zainaipuguli,Tian, Qiang,Xie, Yang,et al. Simultaneous Quantification of Four Compounds in Rat Plasma by HPLC-MS/MS and Its Application to Pharmacokinetic Study after Oral Administration of Pomegranate Flowers[J]. JOURNAL OF CHROMATOGRAPHIC SCIENCE,2021:9.
APA Yisimayili, Zainaipuguli.,Tian, Qiang.,Xie, Yang.,Hu, Pei.,Abdulla, Rahima.,...&Huang, Chenggang.(2021).Simultaneous Quantification of Four Compounds in Rat Plasma by HPLC-MS/MS and Its Application to Pharmacokinetic Study after Oral Administration of Pomegranate Flowers.JOURNAL OF CHROMATOGRAPHIC SCIENCE,9.
MLA Yisimayili, Zainaipuguli,et al."Simultaneous Quantification of Four Compounds in Rat Plasma by HPLC-MS/MS and Its Application to Pharmacokinetic Study after Oral Administration of Pomegranate Flowers".JOURNAL OF CHROMATOGRAPHIC SCIENCE (2021):9.

入库方式： OAI收割

来源：上海药物研究所

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