Discovery of small-molecule modulators of melanogenesis by docking-based virtual screening
文献类型：期刊论文
| 作者 | Abudureyimu, Miernisha1,4,5,6; Zang, Deng4,5,6; Talifu, Ainiwaer3; Zhu, Weiliang2 ; Aisa, Haji Akber4,5,6
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| 刊名 | FUTURE MEDICINAL CHEMISTRY
 |
| 出版日期 | 2021-12-23 |
| 页码 | 11 |
| 关键词 | combination therapy melanogenesis TYR vitiligo Wnt signaling |
| ISSN号 | 1756-8919 |
| DOI | 10.4155/fmc-2021-0150 |
| 通讯作者 | Zhu, Weiliang(wlzhu@simm.ac.cn) ; Aisa, Haji Akber(haji@ms.xjb.ac.cn) |
| 英文摘要 | Background: Vitiligo is a relatively common depigmenting skin disorder. UV light stimulation is often used to obtain repigmentation. Wnt signaling regulates melanocyte differentiation, and expression of TYR is upregulated in narrow-band UVB-treated epidermis. Manipulation of these two pathways by drugs could serve as one of the therapeutic approaches for durable repigmentation. Methods and results: CD9 was identified as a novel TYR activator by virtual screening and bioactivity assay. CD9 activated the Wnt signaling pathway through triggering translocation of beta-catenin from cytoplasm to nucleus. Conclusion: The pathogenesis of vitiligo is complicated and varies with each individual, so combination therapy may be much more suitable for treatment of vitiligo. CD9 could synergize with other anti-inflammatory compounds or autoimmune suppressors to shorten repigmentation time and improve efficacy. |
| WOS关键词 | WNT/BETA-CATENIN ; HUMAN TYROSINASE ; DRUG DISCOVERY ; VITILIGO ; DIFFERENTIATION ; PROLIFERATION ; REQUIRES ; REVEALS ; PATHWAY ; TARGET |
| 资助项目 | Institutes of Drug Discovery and Development, Chinese Academy of Sciences[CASIMM0620183001] ; Central Asia Drug Discovery and Development Centre of Chinese Academy of Science |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000733409800001 |
| 出版者 | FUTURE SCI LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/300806]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Zhu, Weiliang; Aisa, Haji Akber |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Drug Discovery & Design Ctr, State Key Lab Drug Res, Shanghai 211203, Peoples R China 3.Hosp Xinjiang Tradit Uyghur Med, Urumqi 830049, Peoples R China 4.Chinese Acad Sci, Key Lab Plant Resources & Chem Arid Zone, Urumqi 830011, Peoples R China 5.Chinese Acad Sci, State Key Lab Basis Xinjiang Indigenous Med Plant, Urumqi 830011, Peoples R China 6.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Urumqi 830011, Peoples R China |
| 推荐引用方式 GB/T 7714 | Abudureyimu, Miernisha,Zang, Deng,Talifu, Ainiwaer,et al. Discovery of small-molecule modulators of melanogenesis by docking-based virtual screening[J]. FUTURE MEDICINAL CHEMISTRY,2021:11. |
| APA | Abudureyimu, Miernisha,Zang, Deng,Talifu, Ainiwaer,Zhu, Weiliang,&Aisa, Haji Akber.(2021).Discovery of small-molecule modulators of melanogenesis by docking-based virtual screening.FUTURE MEDICINAL CHEMISTRY,11. |
| MLA | Abudureyimu, Miernisha,et al."Discovery of small-molecule modulators of melanogenesis by docking-based virtual screening".FUTURE MEDICINAL CHEMISTRY (2021):11. |
入库方式： OAI收割
来源：上海药物研究所
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