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In-vitro oxidative potential and inflammatory response of ambient PM2.5 in a rural region of Northwest China: Association with chemical compositions and source contribution

文献类型：期刊论文

作者Li, Jianjun1,7; Li, Jin7; Wang, Gehui5,6; Ho, Kin Fai3,4; Han, Jing2; Dai, Wenting7; Wu, Can5,6; Cao, Cong7; Liu, Lang7
刊名ENVIRONMENTAL RESEARCH
出版日期2022-04-01
卷号205页码:10
ISSN号0013-9351
关键词PM2.5 Source apportionment Oxidative stress Inflammatory response
DOI10.1016/j.envres.2021.112466
通讯作者Li, Jianjun(lijj@ieecas.cn) ; Wang, Gehui(ghwang@geo.ecnu.edu.cn)
英文摘要Overproduction of reactive oxygen species (ROS) induced by atmospheric particles and subsequent inflammatory responses are considered as one of the most important pathological mechanisms with regard to the adverse effects of air pollution exposure. In this study, fine particulate matter (PM2.5) samples were collected at a rural site in Guanzhong Basin, Northwest China, in both summer (August 3-23, 2016) and winter (January 5-February 1, 2017). Then, human bronchial epithelial BEAS-2B cells were exposed to the PM2.5, cultured for 24 h, and then assayed for particle-induced ROS and three inflammatory factors (tumor necrosis-alpha (TNF-alpha), interleukin-6 (IL-6), and interferon-gamma (IFN-gamma)) in vitro. The oxidative potential (OP) induced by winter PM2.5 samples was higher than that induced by summertime samples, whereas inflammatory values showed contrasting seasonal variations. Both OP and inflammatory factors were significantly correlated with most chemical compounds in winter, but not in summer, which was thought to be related mainly to the higher contribution from secondary aerosols formed during the warm season. Source apportionment results showed secondary aerosols formation have significant contribution to OP of PM2.5 in both seasons, but the dominant oxidation processes is different. Secondary nitrates-related process was the major contributors regulating the OP in winter; however, secondary sulfates formation were mainly responsible for the ROS responses in summer. For primary emission, biomass burning, rather than coal emission or vehicle exhaust, was the significant source for OP of PM2.5 in winter. In most cases, the source contribution of each inflammatory factor was similar to that of the ROS. Our results highlighted the significant health risk of atmospheric aerosols from biomass burning in the rural regions of Guanzhong Basin, Northwest China.
WOS关键词SECONDARY ORGANIC AEROSOL ; HUMIC-LIKE SUBSTANCES ; PARTICULATE MATTER ; AIR-POLLUTION ; SIZE-DISTRIBUTIONS ; SEASONAL-VARIATION ; ATMOSPHERIC AEROSOLS ; PREMATURE MORTALITY ; SULFATE FORMATION ; FINE PARTICLES
资助项目Strategic Priority Research Program of the Chinese Academy of Sciences[XDB40000000] ; National Natural Science Foundation of China[41977332] ; National Natural Science Foundation of China[41773117] ; Innovation Capability Support Program of Shaanxi[2020KJXX-017] ; Youth Innovation Promotion Association CAS[2020407]
WOS研究方向Environmental Sciences & Ecology ; Public, Environmental & Occupational Health
语种英语
出版者ACADEMIC PRESS INC ELSEVIER SCIENCE
WOS记录号WOS:000730411900002
资助机构Strategic Priority Research Program of the Chinese Academy of Sciences ; National Natural Science Foundation of China ; Innovation Capability Support Program of Shaanxi ; Youth Innovation Promotion Association CAS
源URL[http://ir.ieecas.cn/handle/361006/17314]  
专题地球环境研究所_粉尘与环境研究室
第四纪科学与全球变化卓越创新中心
通讯作者Li, Jianjun; Wang, Gehui
作者单位1.CAS Ctr Excellence Quaternary Sci & Global Change, Xian 710061, Peoples R China
2.Xi An Jiao Tong Univ, Coll Publ Hlth, Hlth Sci Ctr, Xian 710061, Peoples R China
3.Chinese Univ Hong Kong, Shenzhen Res Inst, Shenzhen Municipal Key Lab Hlth Risk Anal, Shenzhen, Peoples R China
4.Chinese Univ Hong Kong, Jockey Club Sch Publ Hlth & Primary Care, Hong Kong, Peoples R China
5.Inst Ecochongming, 3663 N Zhongshan Rd, Shanghai 200062, Peoples R China
6.East China Normal Univ, Sch Geog Sci, Key Lab Geog Informat Sci, Minist Educ, Shanghai 200241, Peoples R China
7.Chinese Acad Sci, Inst Earth Environm, Key Lab Aerosol Chem & Phys, SKLLQG, Xian 710061, Peoples R China
推荐引用方式
GB/T 7714		 Li, Jianjun,Li, Jin,Wang, Gehui,et al. In-vitro oxidative potential and inflammatory response of ambient PM2.5 in a rural region of Northwest China: Association with chemical compositions and source contribution[J]. ENVIRONMENTAL RESEARCH,2022,205:10.
APA Li, Jianjun.,Li, Jin.,Wang, Gehui.,Ho, Kin Fai.,Han, Jing.,...&Liu, Lang.(2022).In-vitro oxidative potential and inflammatory response of ambient PM2.5 in a rural region of Northwest China: Association with chemical compositions and source contribution.ENVIRONMENTAL RESEARCH,205,10.
MLA Li, Jianjun,et al."In-vitro oxidative potential and inflammatory response of ambient PM2.5 in a rural region of Northwest China: Association with chemical compositions and source contribution".ENVIRONMENTAL RESEARCH 205(2022):10.

入库方式： OAI收割

来源：地球环境研究所

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