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Inflammatory and oxidative stress responses of healthy elders to solar-assisted large-scale cleaning system (SALSCS) and changes in ambient air pollution: A quasi-interventional study in Xi'an, China

文献类型：期刊论文

作者Qiu, Hong9; Niu, Xin-Yi7,8; Cao, Jun-Ji5,6; Xu, Hong-Mei4; Xiao, Shun3; Zhang, Ning-Ning6; Xia, Xi7; Shen, Zhen-Xing4; Huang, Yu5,6; Lau, Gabriel Ngar-Cheung2,9
刊名SCIENCE OF THE TOTAL ENVIRONMENT
出版日期2022-02-01
卷号806页码:8
ISSN号0048-9697
关键词Solar-assisted large-scale cleaning system Biomarker Inflammation Oxidative stress Quasi-interventional study
DOI10.1016/j.scitotenv.2021.151217
通讯作者Cao, Jun-Ji(cao@loess.llqg.ac.cn) ; Ho, Kin-Fai(kfho@cuhk.edu.hk)
英文摘要An outdoor solar assisted large-scale cleaning system (SALSCS) was constructed to mitigate the levels of fine particulate matter (PM2.5) in urban areas of Xi'an China, providing a quasi-experimental opportunity to examine the biologic responses to the changes in pollution level. We conducted this outdoor SALSCS based real-world quasiinterventional study to examine the associations of the SALSCS intervention and changes in air pollution levels with the biomarkers of systemic inflammation and oxidative stress in healthy elders. We measured the levels of 8-hydrox-2-deoxyguanosine (8-OHdG), Interlukin-6 (IL-6). as well as tumor necrosis factor alpha (TNF-alpha) from urine samples, and IL-6 from saliva samples of 123 healthy retired participants from interventional/control residential areas in two sampling campaigns. We collected daily 24-h PM2.5 samples in two residential areas during the study periods using mini-volume samplers. Data on PM10, gaseous pollutants and weather factors were collected from the nearest national air quality monitoring stations. We used linear mixed-effect models to examine the percent change in each biomarker associated with the SALSCS intervention and air pollution levels, after adjusting for time trend, seasonality, weather factors and personal characteristics. Results showed that the SALSCS intervention was significantly associated with decreases in the geometric mean of biomarkers by 47.6% (95% confidence interval: 16.5-67.2%) for 8-OHdG, 66% (31.0-83.3%) for TNF-alpha, 41.7% (0.2-65.9%) and 43.4% (13.6-62.9%) for urinary and salivary IL-6, respectively. An inter-quartile range increase of ambient PM 2 . 5 exposure averaged on the day of the collection of bio-samples and the day before (34.1 mu g/m(3)) was associated, albeit non-significantly so, with 22.8%-37.9% increases in the geometric mean of these biomarkers. This study demonstrated that the SALSCS intervention and decreased ambient air pollution exposure results in lower burden of systemic inflammation and oxidative stress in older adults. (C) 2021 Elsevier B.V. All rights reserved.
WOS关键词BEIJING OLYMPICS ; INDOOR PARTICLES ; EXPOSURE ; BIOMARKERS ; FILTRATION ; ASSOCIATION ; CREATININE ; CHILDREN ; DAMAGE ; PANEL
资助项目Key projects from the Shaanxi Government ; Chinese Academy of Sciences ; Chinese University of Hong Kong[4930744]
WOS研究方向Environmental Sciences & Ecology
语种英语
出版者ELSEVIER
WOS记录号WOS:000740225300008
资助机构Key projects from the Shaanxi Government ; Chinese Academy of Sciences ; Chinese University of Hong Kong
源URL[http://ir.ieecas.cn/handle/361006/17375]  
专题地球环境研究所_粉尘与环境研究室
中国科学院气溶胶化学与物理重点实验室
通讯作者Cao, Jun-Ji; Ho, Kin-Fai
作者单位1.Nanyang Technol Univ, Asian Sch Environm, Singapore, Singapore
2.Chinese Univ Hong Kong, Dept Geog & Resource Management, Hong Kong, Peoples R China
3.Shaanxi Normal Univ, Sch Geog & Tourism, Xian, Peoples R China
4.Xi An Jiao Tong Univ, Dept Environm Sci & Engn, Xian, Peoples R China
5.Chinese Acad Sci, Inst Earth Environm, State Key Lab Loess & Quaternary Geol SKLLQG, Xian, Peoples R China
6.Chinese Acad Sci, Inst Earth Environm, Key Lab Aerosol Chem & Phys, Xian, Peoples R China
7.Chinese Univ Hong Kong, Jockey Club Sch Publ Hlth & Primary Care, Hong Kong, Peoples R China
8.Xi An Jiao Tong Univ, Sch Human Settlements & Civil Engn, Xian, Peoples R China
9.Chinese Univ Hong Kong, Inst Environm Energy & Sustainabil, Hong Kong, Peoples R China
推荐引用方式
GB/T 7714		 Qiu, Hong,Niu, Xin-Yi,Cao, Jun-Ji,et al. Inflammatory and oxidative stress responses of healthy elders to solar-assisted large-scale cleaning system (SALSCS) and changes in ambient air pollution: A quasi-interventional study in Xi'an, China[J]. SCIENCE OF THE TOTAL ENVIRONMENT,2022,806:8.
APA Qiu, Hong.,Niu, Xin-Yi.,Cao, Jun-Ji.,Xu, Hong-Mei.,Xiao, Shun.,...&Ho, Kin-Fai.(2022).Inflammatory and oxidative stress responses of healthy elders to solar-assisted large-scale cleaning system (SALSCS) and changes in ambient air pollution: A quasi-interventional study in Xi'an, China.SCIENCE OF THE TOTAL ENVIRONMENT,806,8.
MLA Qiu, Hong,et al."Inflammatory and oxidative stress responses of healthy elders to solar-assisted large-scale cleaning system (SALSCS) and changes in ambient air pollution: A quasi-interventional study in Xi'an, China".SCIENCE OF THE TOTAL ENVIRONMENT 806(2022):8.

入库方式： OAI收割

来源：地球环境研究所

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