Synthesis and catalytic activities of (S)-1-formylpyrrolidine-2-carboxylic acid derivatives for the enantioselective reductions of both a ketone and a ketimine
文献类型：会议论文
| 作者 | Chen, Zhenfei; Zhang, Anjiang; Zhang, Lixue; Zhang, Jing; Lei, Xinxiang |
| 出版日期 | 2008 |
| 关键词 | ASYMMETRIC TRANSFER HYDROGENATION STEREOSELECTIVE REDUCTION IMINES HYDROSILYLATIONS TRICHLOROSILANE ORGANOCATALYST WATER |
| 期号 | 5 |
| DOI | 10.3184/030823408X318433 |
| 英文摘要 | A series of (S)-1-formylpyrrolidine-2-carboxylic acid derivatives (6a-t) have been synthesised and examined as chiral organocatalysts in the asymmetric reduction of both ketone 2 and ketimine 3. These organic activators afforded good to moderate enantioselectivities in the asymmetric reductions of both the ketone and the ketimine. Among them, organic activator 6h displayed the best efficiency, affording a 84% yield and 41% ee in the reduction of the ketone and 75% yield and 52% ee in the reduction of the ketimine. |
| 学科主题 | Chemistry |
| ISSN号 | 1747-5198 |
| 源URL | [http://ir.nimte.ac.cn/handle/174433/23738]  |
| 专题 | 会议专题 会议专题_会议论文 |
| 推荐引用方式 GB/T 7714 | Chen, Zhenfei,Zhang, Anjiang,Zhang, Lixue,et al. Synthesis and catalytic activities of (S)-1-formylpyrrolidine-2-carboxylic acid derivatives for the enantioselective reductions of both a ketone and a ketimine[C]. 见:. |
入库方式： OAI收割
来源：宁波材料技术与工程研究所
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