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Quantitative Proteomics Explore the Potential Targets and Action Mechanisms of Hydroxychloroquine

文献类型：期刊论文

作者Zhao, Jingxiang4,5; Zhao, Zhiqiang3,4; Hou, Wanting4; Jiang, Yue2,4; Liu, Guobin4; Ren, Xuelian4; Liu, Kun2; Liu, Hong1,4,5; Chen, Kaixian1,4,5; Huang, He1,4
刊名MOLECULES
出版日期2022-08-01
卷号27期号:16页码:15
关键词hydroxychloroquine quantitative proteomics thermal proteome profiling
DOI10.3390/molecules27165175
通讯作者Chen, Kaixian(kxchen@simm.ac.cn) ; Huang, He(hhuang@simm.ac.cn)
英文摘要Hydroxychloroquine (HCQ) is an autophagy inhibitor that has been used for the treatment of many diseases, such as malaria, rheumatoid arthritis, systemic lupus erythematosus, and cancer. Despite the therapeutic advances in these diseases, the underlying mechanisms have not been well determined and hinder the rational use of this drug in the future. Here, we explored the possible mechanisms and identified the potential binding targets of HCQ by performing quantitative proteomics and thermal proteome profiling on MIA PaCa-2 cells. This study revealed that HCQ may exert its functions by targeting some autophagy-related proteins such as ribosyldihydronicotinamide dehydrogenase (NQO2) and transport protein Sec23A (SEC23A), or regulating the expression of galectin-8 (LGALS8), mitogen-activated protein kinase 8 (MAPK8), and so on. Furthermore, HCQ may prevent the progression of pancreatic cancer by regulating the expression of nesprin-2 (SYNE2), protein-S-isoprenylcysteine O-methyltransferase (ICMT), and cotranscriptional regulator FAM172A (FAM172A). Together, these findings not only identified potential binding targets for HCQ but also revealed the non-canonical mechanisms of HCQ that may contribute to pancreatic cancer treatment.
WOS关键词AUTOPHAGY ; CHLOROQUINE ; INHIBITION ; INDUCTION ; THERAPIES ; MALARIA ; DISEASE ; GROWTH ; CANCER
资助项目National Natural Science Foundation of China[81973164] ; Shanghai Municipal Science and Technology Major Project
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
语种英语
出版者MDPI
WOS记录号WOS:000845365500001
源URL[http://119.78.100.183/handle/2S10ELR8/302117]  
专题中国科学院上海药物研究所
通讯作者Chen, Kaixian; Huang, He
作者单位1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
2.Northeastern Univ, Sch Mech Engn & Automat, Shenyang 110819, Peoples R China
3.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China
4.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
5.China Pharmaceut Univ, Sch Pharm, Nanjing 211198, Peoples R China
推荐引用方式
GB/T 7714		 Zhao, Jingxiang,Zhao, Zhiqiang,Hou, Wanting,et al. Quantitative Proteomics Explore the Potential Targets and Action Mechanisms of Hydroxychloroquine[J]. MOLECULES,2022,27(16):15.
APA Zhao, Jingxiang.,Zhao, Zhiqiang.,Hou, Wanting.,Jiang, Yue.,Liu, Guobin.,...&Huang, He.(2022).Quantitative Proteomics Explore the Potential Targets and Action Mechanisms of Hydroxychloroquine.MOLECULES,27(16),15.
MLA Zhao, Jingxiang,et al."Quantitative Proteomics Explore the Potential Targets and Action Mechanisms of Hydroxychloroquine".MOLECULES 27.16(2022):15.

入库方式： OAI收割

来源：上海药物研究所

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