Bioinspired large Stokes shift small molecular dyes for biomedical fluorescence imaging
文献类型：期刊论文
| 作者 | Chen, Hao4,5; Liu, Lingjun2,3,5; Qian, Kun5; Liu, Hailong5; Wang, Zhiming5; Gao, Feng5; Qu, Chunrong5; Dai, Wenhao5; Lin, Daizong5; Chen, Kaixian2,3,4,5
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| 刊名 | SCIENCE ADVANCES
 |
| 出版日期 | 2022-08-12 |
| 卷号 | 8期号:32页码:13 |
| ISSN号 | 2375-2548 |
| DOI | 10.1126/sciadv.abo3289 |
| 通讯作者 | Liu, Hong(hliu@simm.ac.cn) ; Cheng, Zhen(zcheng@simm.ac.cn) |
| 英文摘要 | Long Stokes shift dyes that minimize cross-talk between the excitation source and fluorescent emission to improve the signal-to-background ratio are highly desired for fluorescence imaging. However, simple small molecular dyes with large Stokes shift (more than 120 nanometers) and near- infrared ( NIR) emissions have been rarely reported so far. Here, inspired by the chromophore chemical structure of fluorescent proteins, we designed and synthesized a series of styrene oxazolone dyes (SODs) with simple synthetic methods, which show NIR emissions (>650 nanometers) with long Stokes shift (ranged from 136 to 198 nanometers) and small molecular weight (<450 daltons). The most promising SOD9 shows rapid renal excretion and blood-brain barrier passing properties. After functioning with the mitochondrial-targeted triphenylphosphonium (TPP) group, the resulting SOD9-TPP can be engineered for head-neck tumor imaging, fluorescence image-guided surgery, brain neuroimaging, and on-site pathologic analysis. In summary, our findings add an essential small molecular dye category to the classical dyes. |
| WOS关键词 | IN-VIVO ; RATIONAL DESIGN ; CHEMICAL PROBES ; AUTOFLUORESCENCE ; RHODAMINE |
| 资助项目 | National Science and Technology Innovation 2030 Major Project of China[2021ZD0203900] ; Shanghai Municipal Science and Technology Major Project ; National Natural Science Foundation of China[82071976] ; National Natural Science Foundation of China[91953108] ; National Natural Science Foundation of China[82130105] ; National Natural Science Foundation of China[82121005] ; Lingang Laboratory grant[LG-QS-202206-01] ; Lingang Laboratory grant[LG202103-03-03] |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| 出版者 | AMER ASSOC ADVANCEMENT SCIENCE |
| WOS记录号 | WOS:000841491100019 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/302296]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Liu, Hong; Cheng, Zhen |
| 作者单位 | 1.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Shandong, Peoples R China 2.China Pharmaceut Univ, Dept Med Chem, 24 Tong Jia Xiang, Nanjing 210009, Jiangsu, Peoples R China 3.China Pharmaceut Univ, State Key Lab Nat Med, 24 Tong Jia Xiang, Nanjing 210009, Jiangsu, Peoples R China 4.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 5.Chinese Acad Sci, Mol Imaging Ctr, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Hao,Liu, Lingjun,Qian, Kun,et al. Bioinspired large Stokes shift small molecular dyes for biomedical fluorescence imaging[J]. SCIENCE ADVANCES,2022,8(32):13. |
| APA | Chen, Hao.,Liu, Lingjun.,Qian, Kun.,Liu, Hailong.,Wang, Zhiming.,...&Cheng, Zhen.(2022).Bioinspired large Stokes shift small molecular dyes for biomedical fluorescence imaging.SCIENCE ADVANCES,8(32),13. |
| MLA | Chen, Hao,et al."Bioinspired large Stokes shift small molecular dyes for biomedical fluorescence imaging".SCIENCE ADVANCES 8.32(2022):13. |
入库方式： OAI收割
来源：上海药物研究所
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