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Interplay of receptor-ligand binding and lipid domain formation during cell adhesion

文献类型：期刊论文

作者Li L(李龙); Hu, Jinglei7; Rozycki, Bartosz4; Ji, Jing3; Song F(宋凡)
刊名FRONTIERS IN MOLECULAR BIOSCIENCES
出版日期2022-09
卷号9页码:1019477
关键词cell adhesion receptor-tigand binding lipid domain formation binding affinity binding cooperativity phase separation
DOI10.3389/fmolb.2022.1019477
英文摘要Cell adhesion involved in biological processes such as cell migration, immune responses, and cancer metastasis, is mediated by the specific binding of receptor and ligand proteins. Some of these proteins exhibit affinity for nanoscale lipid clusters in cell membranes. A key question is how these nanoscale lipid clusters influence and react to the receptor-ligand binding during cell adhesion. In this article, we review recent computational studies that shed new light on the interplay of the receptor-ligand binding and the formation of lipid domains in adhering membranes. These studies indicate that the receptor- ligand binding promotes coalescence of lipid clusters into mesoscale domains, which, in turn, enhances both the affinity and cooperativity of the receptor-ligand binding in cell-cell adhesion with mobile ligands. In contrast, in the case of cell-extracellular matrix adhesion with immobile ligands, the receptor- ligand binding and the lipid cluster coalescence can be correlated or anti-correlated, depending strongly on the ligand distribution. These findings deepen our understanding of correlations between cell adhesion and membrane heterogeneities.
学科主题Biochemistry & Molecular Biology
分类号二类/Q1
语种英语
WOS记录号WOS:000864008900001
资助机构National Natural Science Foundation of China [11902327, 1197204, 21973040, 12272388, 12232019, 22161132012] ; Youth In11ation Promotion Association CAS ; National Science Centre of Poland [2021/40/Q/NZ1/00017]
其他责任者Hu, JL (corresponding author), Nanjing Univ, Kuang Yaming Honors Sch, Nanjing, Peoples R China. ; Hu, JL (corresponding author), Nanjing Univ, Inst Brain Sci, Nanjing, Peoples R China. ; Rozycki, B (corresponding author), Polish Acad Sci, Inst Phys, Warsaw, Poland. ; Ji, J (corresponding author), Beihang Univ, Key Lab Biomech & Mechanobiol, Minist Educ, Beijing Adv In11at Ctr Biomed Engn,Sch Biol Sci, Beijing, Peoples R China.
源URL[http://dspace.imech.ac.cn/handle/311007/90168]  
专题力学研究所_非线性力学国家重点实验室
作者单位1.Univ Chinese Acad Sci, Sch Engn Sci, Beijing, Peoples R China
2.Beihang Univ, Key Lab Biomech & Mechanobiol, Minist Educ, Beijing Adv In11at Ctr Biomed Engn,Sch Biol Sci, Beijing, Peoples R China
3.Polish Acad Sci, Inst Phys, Warsaw, Poland
4.Chinese Acad Sci, Inst Mech, Beijing Key Lab Engn Construct & Mechanobiol, Beijing, Peoples R China
5.Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech, Beijing, Peoples R China
6.Nanjing Univ, Inst Brain Sci, Nanjing, Peoples R China
7.Nanjing Univ, Kuang Yaming Honors Sch, Nanjing, Peoples R China
推荐引用方式
GB/T 7714		 Li L,Hu, Jinglei,Rozycki, Bartosz,et al. Interplay of receptor-ligand binding and lipid domain formation during cell adhesion[J]. FRONTIERS IN MOLECULAR BIOSCIENCES,2022,9:1019477.
APA 李龙,Hu, Jinglei,Rozycki, Bartosz,Ji, Jing,&宋凡.(2022).Interplay of receptor-ligand binding and lipid domain formation during cell adhesion.FRONTIERS IN MOLECULAR BIOSCIENCES,9,1019477.
MLA 李龙,et al."Interplay of receptor-ligand binding and lipid domain formation during cell adhesion".FRONTIERS IN MOLECULAR BIOSCIENCES 9(2022):1019477.

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来源：力学研究所

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