中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 上海药物研究所
  3. 中国科学院上海药物研究所
Synthesis and anti-SARS-CoV-2 activity of deuterated GS-441524 analogs

文献类型：期刊论文

作者Zheng, Wei1,5; Hu, Tianwen1,4; Zhang, Yumin3; Wei, Daibao1,4; Xie, Yuanchao2; Shen, Jingshan1,5
刊名TETRAHEDRON LETTERS
出版日期2022-08-17
卷号104页码:9
关键词SARS-CoV-2 GS-441524 Deuterated
ISSN号0040-4039
DOI10.1016/j.tetlet.2022.154012
通讯作者Xie, Yuanchao(xieyuanchao@lglab.ac.cn) ; Shen, Jingshan(shenjingshan@simm.ac.cn)
英文摘要The COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is continuing to spread around the world. GS-441524 is the parent nucleoside of remdesivir which is the first drug approved for the treatment of COVID-19, and demonstrates strong activity against SARS-Cov-2 in vitro and in vivo. Herein, we reported the synthesis of a series of deuterated GS-441524 analogs, which had deuterium atoms up to five at the ribose and the nucleobase moieties. Compared to GS-441524, all the deuterated compounds showed similar inhibitory activities against SARS-CoV-2 in vitro. (C) 2022 Elsevier Ltd. All rights reserved.
WOS关键词DEUTERIUM ; DRUG
资助项目Shanghai Municipal Science and Technology Major Project ; Lingang Laboratory[LG202103-04-04]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000864722800007
出版者PERGAMON-ELSEVIER SCIENCE LTD
源URL[http://119.78.100.183/handle/2S10ELR8/302766]  
专题中国科学院上海药物研究所
通讯作者Xie, Yuanchao; Shen, Jingshan
作者单位1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
2.Lingang Lab, Shanghai 200031, Peoples R China
3.Chinese Acad Sci, Ctr Biosafety Megasci, Wuhan Inst Virol, State Key Lab Virol, Wuhan 430071, Hubei, Peoples R China
4.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, State Key Lab Basis Xinjiang Indigenous Med Plant, South Beijing Rd 40-1, Urumqi 830011, Peoples R China
5.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Zheng, Wei,Hu, Tianwen,Zhang, Yumin,et al. Synthesis and anti-SARS-CoV-2 activity of deuterated GS-441524 analogs[J]. TETRAHEDRON LETTERS,2022,104:9.
APA Zheng, Wei,Hu, Tianwen,Zhang, Yumin,Wei, Daibao,Xie, Yuanchao,&Shen, Jingshan.(2022).Synthesis and anti-SARS-CoV-2 activity of deuterated GS-441524 analogs.TETRAHEDRON LETTERS,104,9.
MLA Zheng, Wei,et al."Synthesis and anti-SARS-CoV-2 activity of deuterated GS-441524 analogs".TETRAHEDRON LETTERS 104(2022):9.

入库方式： OAI收割

来源：上海药物研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。