Hypoglycemic ingredients identification of Rheum tanguticum Maxim. ex Balf. by UHPLC-triple-TOF-MS/MS and interrelationships between ingredients content and glycosidase inhibitory activities
文献类型：期刊论文
| 作者 | Yue, HL; Jiang, SR; Wang, LY; Banma, CL; Zhou, GY ; Shao, Y; Tao, YD; Zhao, XH
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| 刊名 | INDUSTRIAL CROPS AND PRODUCTS
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| 出版日期 | 2022 |
| 卷号 | 178 |
| 英文摘要 | Rheum tanguticum Maxim. ex Balf. (RT), mainly is mainly produced in Gansu, Qinghai, Tibet and Sichuan of China, has long been used as a medicine for purging fire and quenching thirst. The RTR-2 (Rheum tanguticum root extract without polysaccharides and protein) had strong inhibitory activities against a-amylase, maltase and sucrase with the IC50 0.042 mg/mL, 0.124 mg/mL and 0.097 mg/mL, respectively. In addition, RTR-2 could significantly reduce PBG level of diabetic mice in starch/maltose/sucrose tolerance test. Total 48 constituents including 12 anthraquinones, 4 bianthmnes, 8 flavans, 3 stilbenes, 5 phenylbutanones, 4 naphthosides, 8 glucose gallates and 4 phenolic acids were determined in RTR-2 by UPLC-Triple-TOF/MS analysis of molecular ion, main fragments, retention time, and references. Furthermore, the components such as flavan ((-)-epicatechin 3-O-gallate) and phenylbutanone (lindleyin) were demonstrated to have sucrase and maltase inhibitory activites, and might be the main hypoglycemic active ingredients of RTR-2 extract. All these results offered an exhaustive knowledge for the hypoglycemic compounds of Rheum tanguticum, which was conducive to its further development and utilization as a valuable source of hypoglycemic plant in pharmaceutical industry. |
| 源URL | [http://210.75.249.4/handle/363003/61260]  |
| 专题 | 西北高原生物研究所_中国科学院西北高原生物研究所 |
| 推荐引用方式 GB/T 7714 | Yue, HL,Jiang, SR,Wang, LY,et al. Hypoglycemic ingredients identification of Rheum tanguticum Maxim. ex Balf. by UHPLC-triple-TOF-MS/MS and interrelationships between ingredients content and glycosidase inhibitory activities[J]. INDUSTRIAL CROPS AND PRODUCTS,2022,178. |
| APA | Yue, HL.,Jiang, SR.,Wang, LY.,Banma, CL.,Zhou, GY.,...&Zhao, XH.(2022).Hypoglycemic ingredients identification of Rheum tanguticum Maxim. ex Balf. by UHPLC-triple-TOF-MS/MS and interrelationships between ingredients content and glycosidase inhibitory activities.INDUSTRIAL CROPS AND PRODUCTS,178. |
| MLA | Yue, HL,et al."Hypoglycemic ingredients identification of Rheum tanguticum Maxim. ex Balf. by UHPLC-triple-TOF-MS/MS and interrelationships between ingredients content and glycosidase inhibitory activities".INDUSTRIAL CROPS AND PRODUCTS 178(2022). |
入库方式： OAI收割
来源：西北高原生物研究所
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