Intercellular Receptor-ligand Binding: Effect of Protein-membrane Interaction
文献类型:期刊论文
作者 | Li, Long3,4,5,6; Ji, Jing2; Song, Fan1,3,4; Hu, Jinglei5,6; Song F(宋凡); Li L(李龙); Li L(李龙) |
刊名 | JOURNAL OF MOLECULAR BIOLOGY |
出版日期 | 2023-01-15 |
卷号 | 435期号:1页码:17 |
ISSN号 | 0022-2836 |
关键词 | Protein-membrane interaction Intercellular receptor-ligand binding Membrane fluctuations and curvature Glycocalyx Lipid raft |
DOI | 10.1016/j.jmb.2022.167787 |
通讯作者 | Ji, Jing(09714@buaa.edu.cn) ; Hu, Jinglei(hujinglei@nju.edu.cn) |
英文摘要 | Gaining insights into the intercellular receptor-ligand binding is of great importance for understanding numerous physiological and pathological processes, and stimulating new strategies in drug design and discovery. In contrast to the in vitro protein interaction in solution, the anchored receptor and ligand mole-cules interact with membrane in situ, which affects the intercellular receptor-ligand binding. Here, we review theoretical, simulation and experimental works regarding the regulatory effects of protein -membrane interactions on intercellular receptor-ligand binding mainly from the following aspects: mem-brane fluctuations, membrane curvature, glycocalyx, and lipid raft. In addition, we discuss biomedical sig-nificances and possible research directions to advance the field and highlight the importance of understanding of coupling effects of these factors in pharmaceutical development.(c) 2022 Elsevier Ltd. All rights reserved. |
WOS关键词 | ATOMIC-FORCE MICROSCOPY ; CELL-ADHESION MOLECULES ; LIPID RAFTS ; ANCHORED RECEPTORS ; PLASMA-MEMBRANE ; CURVATURE GENERATION ; SIGNALING MOLECULES ; STRUCTURAL INSIGHTS ; ELASTIC PROPERTIES ; PHYSICAL BIOLOGY |
资助项目 | National Natural Science Foundation of China[11902327] ; National Natural Science Foundation of China[11972041] ; National Natural Science Foundation of China[22161132012] ; National Natural Science Foundation of China[21973040] ; Youth Innovation Promotion Association CAS |
WOS研究方向 | Biochemistry & Molecular Biology |
语种 | 英语 |
WOS记录号 | WOS:000913850700001 |
资助机构 | National Natural Science Foundation of China ; Youth Innovation Promotion Association CAS |
源URL | [http://dspace.imech.ac.cn/handle/311007/91575] |
专题 | 力学研究所_非线性力学国家重点实验室 |
通讯作者 | Ji, Jing; Hu, Jinglei |
作者单位 | 1.Univ Chinese Acad Sci, Sch Engn Sci, Beijing 100049, Peoples R China 2.Beihang Univ, Beijing Adv Innovat Ctr Biomed Engn, Key Lab Biomech & Mechanobiol, Minist Educ,Sch Biol Sci & Med Engn, Beijing 100083, Peoples R China 3.Chinese Acad Sci, Inst Mech, Beijing Key Lab Engn Construct & Mechanobiol, Beijing 100190, Peoples R China 4.Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech, Beijing 100190, Peoples R China 5.Nanjing Univ, Inst Brain Sci, Nanjing 210023, Peoples R China 6.Nanjing Univ, Kuang Yaming Honors Sch, Nanjing 210023, Peoples R China |
推荐引用方式 GB/T 7714 | Li, Long,Ji, Jing,Song, Fan,et al. Intercellular Receptor-ligand Binding: Effect of Protein-membrane Interaction[J]. JOURNAL OF MOLECULAR BIOLOGY,2023,435(1):17. |
APA | Li, Long.,Ji, Jing.,Song, Fan.,Hu, Jinglei.,宋凡.,...&李龙.(2023).Intercellular Receptor-ligand Binding: Effect of Protein-membrane Interaction.JOURNAL OF MOLECULAR BIOLOGY,435(1),17. |
MLA | Li, Long,et al."Intercellular Receptor-ligand Binding: Effect of Protein-membrane Interaction".JOURNAL OF MOLECULAR BIOLOGY 435.1(2023):17. |
入库方式: OAI收割
来源:力学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。