中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Intercellular Receptor-ligand Binding: Effect of Protein-membrane Interaction

文献类型:期刊论文

作者Li, Long3,4,5,6; Ji, Jing2; Song, Fan1,3,4; Hu, Jinglei5,6; Song F(宋凡); Li L(李龙); Li L(李龙)
刊名JOURNAL OF MOLECULAR BIOLOGY
出版日期2023-01-15
卷号435期号:1页码:17
ISSN号0022-2836
关键词Protein-membrane interaction Intercellular receptor-ligand binding Membrane fluctuations and curvature Glycocalyx Lipid raft
DOI10.1016/j.jmb.2022.167787
通讯作者Ji, Jing(09714@buaa.edu.cn) ; Hu, Jinglei(hujinglei@nju.edu.cn)
英文摘要Gaining insights into the intercellular receptor-ligand binding is of great importance for understanding numerous physiological and pathological processes, and stimulating new strategies in drug design and discovery. In contrast to the in vitro protein interaction in solution, the anchored receptor and ligand mole-cules interact with membrane in situ, which affects the intercellular receptor-ligand binding. Here, we review theoretical, simulation and experimental works regarding the regulatory effects of protein -membrane interactions on intercellular receptor-ligand binding mainly from the following aspects: mem-brane fluctuations, membrane curvature, glycocalyx, and lipid raft. In addition, we discuss biomedical sig-nificances and possible research directions to advance the field and highlight the importance of understanding of coupling effects of these factors in pharmaceutical development.(c) 2022 Elsevier Ltd. All rights reserved.
WOS关键词ATOMIC-FORCE MICROSCOPY ; CELL-ADHESION MOLECULES ; LIPID RAFTS ; ANCHORED RECEPTORS ; PLASMA-MEMBRANE ; CURVATURE GENERATION ; SIGNALING MOLECULES ; STRUCTURAL INSIGHTS ; ELASTIC PROPERTIES ; PHYSICAL BIOLOGY
资助项目National Natural Science Foundation of China[11902327] ; National Natural Science Foundation of China[11972041] ; National Natural Science Foundation of China[22161132012] ; National Natural Science Foundation of China[21973040] ; Youth Innovation Promotion Association CAS
WOS研究方向Biochemistry & Molecular Biology
语种英语
WOS记录号WOS:000913850700001
资助机构National Natural Science Foundation of China ; Youth Innovation Promotion Association CAS
源URL[http://dspace.imech.ac.cn/handle/311007/91575]  
专题力学研究所_非线性力学国家重点实验室
通讯作者Ji, Jing; Hu, Jinglei
作者单位1.Univ Chinese Acad Sci, Sch Engn Sci, Beijing 100049, Peoples R China
2.Beihang Univ, Beijing Adv Innovat Ctr Biomed Engn, Key Lab Biomech & Mechanobiol, Minist Educ,Sch Biol Sci & Med Engn, Beijing 100083, Peoples R China
3.Chinese Acad Sci, Inst Mech, Beijing Key Lab Engn Construct & Mechanobiol, Beijing 100190, Peoples R China
4.Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech, Beijing 100190, Peoples R China
5.Nanjing Univ, Inst Brain Sci, Nanjing 210023, Peoples R China
6.Nanjing Univ, Kuang Yaming Honors Sch, Nanjing 210023, Peoples R China
推荐引用方式
GB/T 7714
Li, Long,Ji, Jing,Song, Fan,et al. Intercellular Receptor-ligand Binding: Effect of Protein-membrane Interaction[J]. JOURNAL OF MOLECULAR BIOLOGY,2023,435(1):17.
APA Li, Long.,Ji, Jing.,Song, Fan.,Hu, Jinglei.,宋凡.,...&李龙.(2023).Intercellular Receptor-ligand Binding: Effect of Protein-membrane Interaction.JOURNAL OF MOLECULAR BIOLOGY,435(1),17.
MLA Li, Long,et al."Intercellular Receptor-ligand Binding: Effect of Protein-membrane Interaction".JOURNAL OF MOLECULAR BIOLOGY 435.1(2023):17.

入库方式: OAI收割

来源:力学研究所

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