Synthesis of telmisartan via oxidative cyclization
文献类型：期刊论文
| 作者 | Li, Rui2,3; Khakimov, Makhmudjon1,3; Zhu, Fuqiang4; Jiang, Xiangrui1,3 ; Shen, Jingshan1,2,3
|
| 刊名 | TETRAHEDRON
 |
| 出版日期 | 2023-01-09 |
| 卷号 | 130页码:5 |
| ISSN号 | 0040-4020 |
| 关键词 | Telmisartan Amidine Cyclization Oxidative |
| DOI | 10.1016/j.tet.2022.133168 |
| 通讯作者 | Shen, Jingshan(shenjingshan@simm.ac.cn) |
| 英文摘要 | An efficient synthesis has been developed for telmisartan. The key strategy is the construction of substituted bis-benzimidazole 11b by oxidative cyclization of substituted amidine 15 with bis(tri-fluoroacetoxy)iodobenzene. In this research, we provided telmisartan from the starting compound 12 in an overall yield of 61.5% by four steps while avoiding many issues previously reported.(c) 2022 Elsevier Ltd. All rights reserved. |
| WOS关键词 | BENZIMIDAZOLES ; ANNULATION ; AROMATICS ; EFFICIENT ; NITRATION |
| 资助项目 | Special Foundation of Chinese Academy of Sciences for strategic pilot technology ; Science and Technology Commission of Shanghai Municipality ; [XDA12050411] ; [18431907100] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| WOS记录号 | WOS:000911097200001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/303808]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Shen, Jingshan |
| 作者单位 | 1.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 2.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, CAS Key Lab Receptor Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China 4.Topharman Shanghai Co Ltd, Zhangjiang Hitech Pk, 388 Jialilue Rd, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Rui,Khakimov, Makhmudjon,Zhu, Fuqiang,et al. Synthesis of telmisartan via oxidative cyclization[J]. TETRAHEDRON,2023,130:5. |
| APA | Li, Rui,Khakimov, Makhmudjon,Zhu, Fuqiang,Jiang, Xiangrui,&Shen, Jingshan.(2023).Synthesis of telmisartan via oxidative cyclization.TETRAHEDRON,130,5. |
| MLA | Li, Rui,et al."Synthesis of telmisartan via oxidative cyclization".TETRAHEDRON 130(2023):5. |
入库方式： OAI收割
来源：上海药物研究所
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