Roles of hydroxyeicosatetraenoic acids in diabetes (HETEs and diabetes)
文献类型：期刊论文
| 作者 | Dong, Linyue1; Wang, Heyao2 ; Chen, Kaixian2; Li, Yiming1
|
| 刊名 | BIOMEDICINE & PHARMACOTHERAPY
 |
| 出版日期 | 2022-12-01 |
| 卷号 | 156页码:13 |
| 关键词 | 5-HETE 12-HETE 15-HETE 20-HETE Lipoxygenases Diabetes Obesity |
| ISSN号 | 0753-3322 |
| DOI | 10.1016/j.biopha.2022.113981 |
| 通讯作者 | Li, Yiming(ymlius@163.com) |
| 英文摘要 | Hydroxyeicosatetraenoic acids (HETEs) are metabolites of arachidonate acid (AA) oxidized by lipoxygenases or cytochrome P450 enzymes (CYP450). Since lipoxygenases and CYP450 enzymes widely exist in different organs and tissues, HETEs play significant roles in normal physiological and pathophysiological conditions. Mounting evidence has shown that HETEs play roles in modulation of inflammation during diabetes development. And accumulating evidence suggests that in prediabetic conditions, HETEs have already impacted on adipose tissue, kidney, heart, and islet. In the current review, we focused on the role of specific HETEs, namely 5-HETE, 12-HETE, 15-HETE and 20-HETE in diabetes, and highlighted their effects in the development of diabetes and diabetes-related complications. In conclusion, elucidation of HETEs' impacts on different organs that contribute to the development of diabetes leads to identification of novel therapeutic modalities. |
| WOS关键词 | SMOOTH-MUSCLE-CELLS ; OBESITY-ASSOCIATED INFLAMMATION ; ENDOPLASMIC-RETICULUM STRESS ; VISCERAL ADIPOSE-TISSUE ; NECROSIS-FACTOR-ALPHA ; 20-HYDROXYEICOSATETRAENOIC ACID ; OXIDATIVE STRESS ; INSULIN-SECRETION ; 12(S)-HYDROXYEICOSATETRAENOIC ACID ; BETA-CELLS |
| 资助项目 | National Natural Science Foundation of China[81973458] ; program of Shanghai E-research Institute of Bioactive Constituents in Traditional Chinese Medicine ; SIMM-SHUTCM Joint Innovation Research Program(2022) ; National Key Science and Technology Infrastructure (Shanghai) Translational Medicine Open Program[TMSK-2021-404] |
| WOS研究方向 | Research & Experimental Medicine ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000904403400001 |
| 出版者 | ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/304052]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Li, Yiming |
| 作者单位 | 1.Shanghai Univ Tradit Chinese Med, Dept TCM Chem, Shanghai, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Dong, Linyue,Wang, Heyao,Chen, Kaixian,et al. Roles of hydroxyeicosatetraenoic acids in diabetes (HETEs and diabetes)[J]. BIOMEDICINE & PHARMACOTHERAPY,2022,156:13. |
| APA | Dong, Linyue,Wang, Heyao,Chen, Kaixian,&Li, Yiming.(2022).Roles of hydroxyeicosatetraenoic acids in diabetes (HETEs and diabetes).BIOMEDICINE & PHARMACOTHERAPY,156,13. |
| MLA | Dong, Linyue,et al."Roles of hydroxyeicosatetraenoic acids in diabetes (HETEs and diabetes)".BIOMEDICINE & PHARMACOTHERAPY 156(2022):13. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。