Toad venom bufadienolides and bufotoxins: An updated review
文献类型：期刊论文
| 作者 | Asrorov, Akmal M.1,2,3,4; Kayumov, Muzaffar2; Mukhamedov, Nurkhodja2; Yashinov, Ansor4,5; Mirakhmetova, Ziyoda2; Huang, Yongzhuo4,5 ; Yili, Abulimiti6; Aisa, Haji Akber6; Tashmukhamedov, Mugrajitdin2; Salikhov, Shavkat2
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| 刊名 | DRUG DEVELOPMENT RESEARCH
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| 出版日期 | 2023-05-08 |
| 页码 | 24 |
| ISSN号 | 0272-4391 |
| 关键词 | arenobufagin bufadienolides bufalin bufotalin cinobufagin cinobufotalin gamabufotalin |
| DOI | 10.1002/ddr.22072 |
| 通讯作者 | Asrorov, Akmal M.(akmal84a@gmail.com) |
| 英文摘要 | Bufadienolides, naturally found in toad venoms having steroid-like structures, reveal antiproliferative effects at low doses. However, their application as anticancer drugs is strongly prevented by their Na+/K+-ATPase binding activities. Although several kinds of research were dedicated to moderating their Na+/K+-ATPase binding activity, still deeper fundamental knowledge is required to bring these findings into medical practice. In this work, we reviewed data related to anticancer activity of bufadienolides such as bufalin, arenobufagin, bufotalin, gamabufotalin, cinobufotalin, and cinobufagin and their derivatives. Bufotoxins, derivatives of bufadienolides containing polar molecules mainly belonging to argininyl residues, are reviewed as well. The established structures of bufotoxins have been compiled into a one-page figure to review their structures. We also highlighted advances in the structure-modification of the structure of compounds in this class. Drug delivery approaches to target these compounds to tumor cells were discussed in one section. The issues related to extraction, identification, and quantification are separated into another section. |
| WOS关键词 | HEPATOCELLULAR-CARCINOMA CELLS ; BUFALIN INDUCES APOPTOSIS ; IN-VITRO ; ANTIPROLIFERATIVE ACTIVITY ; POLYMERIC PRODRUG ; CELLULAR UPTAKE ; CYCLE ARREST ; CANCER ; ANTICANCER ; NANOPARTICLES |
| 资助项目 | Ministry of Innovative Development of the Republic of Uzbekistan ; Chinese Academy of Sciences |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | WILEY |
| WOS记录号 | WOS:000982846300001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/306493]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Asrorov, Akmal M. |
| 作者单位 | 1.Uzbek Acad Sci, Inst Bioorgan Chem, Tashkent 100125, Uzbekistan 2.Uzbek Acad Sci, Inst Bioorgan Chem, Tashkent, Uzbekistan 3.Natl Univ Uzbekistan, Dept Nat Subst Chem, Tashkent, Uzbekistan 4.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai, Peoples R China 5.Univ Chinese Acad Sci UCAS, Beijing, Peoples R China 6.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Urumqi, Peoples R China |
| 推荐引用方式 GB/T 7714 | Asrorov, Akmal M.,Kayumov, Muzaffar,Mukhamedov, Nurkhodja,et al. Toad venom bufadienolides and bufotoxins: An updated review[J]. DRUG DEVELOPMENT RESEARCH,2023:24. |
| APA | Asrorov, Akmal M..,Kayumov, Muzaffar.,Mukhamedov, Nurkhodja.,Yashinov, Ansor.,Mirakhmetova, Ziyoda.,...&Mirzaakhmedov, Sharafitdin.(2023).Toad venom bufadienolides and bufotoxins: An updated review.DRUG DEVELOPMENT RESEARCH,24. |
| MLA | Asrorov, Akmal M.,et al."Toad venom bufadienolides and bufotoxins: An updated review".DRUG DEVELOPMENT RESEARCH (2023):24. |
入库方式： OAI收割
来源：上海药物研究所
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