Rh(III)-Catalyzed Synthesis of Substituted Isoindoles through a Direct C-H Activation/[4+1] Annulation and Acyl Migration Cascade of Oxadiazolones with Diazo Compounds
文献类型：期刊论文
| 作者 | Yang, Xiaohao1,2; Ren, Hairu1,2; Zhou, Shengbin1,2; Li, Chunpu1,2,3; Liu, Chaoyi1,2; Zhou, Yu1,2,3 ; He, Guoxue1,2; Liu, Hong1,2,3
|
| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2023-05-01 |
| 页码 | 5 |
| ISSN号 | 1523-7060 |
| DOI | 10.1021/acs.orglett.3c00547 |
| 通讯作者 | He, Guoxue(heguoxue@ucas.ac.cn) ; Liu, Hong(hliu@simm.ac.cn) |
| 英文摘要 | A Rh(III)-catalyzed C-H bond activation for the synthesis of fused 2H-isoindole scaffolds from oxadiazolones with diazo compounds was developed. The reaction proceeded through C-H activation of oxadiazolones/[4 + 1] annulation, intramolecular cyclization, and an unusual acyl migration cascade to afford target scaffolds with good yields. These 2H-isoindole derivatives could be further transformed into intriguing drug privileged scaffolds. |
| WOS关键词 | FACILE SYNTHESIS ; ACIDS ; BIOSYNTHESIS ; DERIVATIVES |
| 资助项目 | National Natural Science Foundation of China[82130105] ; National Natural Science Foundation of China[82121005] ; National Natural Science Foundation of China[91953108] ; Hangzhou institute for advanced study[2022ZZ01015] ; Hangzhou institute for advanced study[2022ZZ01012] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000984374700001 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/306496]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | He, Guoxue; Liu, Hong |
| 作者单位 | 1.Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Sch Pharmaceut Sci & Technol, Hangzhou 310024, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Xiaohao,Ren, Hairu,Zhou, Shengbin,et al. Rh(III)-Catalyzed Synthesis of Substituted Isoindoles through a Direct C-H Activation/[4+1] Annulation and Acyl Migration Cascade of Oxadiazolones with Diazo Compounds[J]. ORGANIC LETTERS,2023:5. |
| APA | Yang, Xiaohao.,Ren, Hairu.,Zhou, Shengbin.,Li, Chunpu.,Liu, Chaoyi.,...&Liu, Hong.(2023).Rh(III)-Catalyzed Synthesis of Substituted Isoindoles through a Direct C-H Activation/[4+1] Annulation and Acyl Migration Cascade of Oxadiazolones with Diazo Compounds.ORGANIC LETTERS,5. |
| MLA | Yang, Xiaohao,et al."Rh(III)-Catalyzed Synthesis of Substituted Isoindoles through a Direct C-H Activation/[4+1] Annulation and Acyl Migration Cascade of Oxadiazolones with Diazo Compounds".ORGANIC LETTERS (2023):5. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。