中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 上海药物研究所
  3. 中国科学院上海药物研究所
Root-Extracted lignanamides from Limonium gmelinii (Willd.) Kuntze with a potential PTP1B inhibitory activity by regulating PI3K/AKT signaling pathway

文献类型：期刊论文

作者Tuohongerbieke, Amanguli1,2; Liu, Liu1,2; Li, Jun1,2; Xin, Xuelei1,2; Aisa, Haji Akber1,2,3
刊名BIOORGANIC CHEMISTRY
出版日期2023-03-01
卷号132页码:9
ISSN号0045-2068
关键词Limonium gmelinii (Willd ) Kuntze Plumbaginaceae Lignanamides Protein tyrosine phosphatase 1B inhibitors PI3K AKT Signaling Pathway
DOI10.1016/j.bioorg.2023.106348
通讯作者Aisa, Haji Akber(haji@ms.xjb.ac.cn)
英文摘要The phytochemical study of Limonium gmelinii roots resulted in the isolation of five lignanamides (1-5). Among them, limoniumins J, K, and M (1, 2, and 4) are undescribed compounds, limoniumin L (3) is a new naturally occurring lignanamide, and limoniumin B (5) is a known compound which showed PTP1B inhibition activity with an IC50 value of 5.05 +/- 2.44 mu M in our previous work. Spectroscopic data analysis, including 1D and 2D NMR and HRESIMS experiments, established the chemical structures of limoniumins J - M (1-4). Compounds 1-4 showed PTP1B inhibition activity, among which compound 3 showed the most potent PTP1B inhibition with an IC50 value of 2.07 +/- 0.05 mu M. Compounds 3 and 5 could significantly increase cellular glucose consumption and glucose uptake in L6 muscle cells and could synergize with insulin to promote glucose consumption and glucose uptake in a concentration-dependent manner. The treatment of compound 3 also promoted glycogen synthesis in skeletal muscle cells. Western blot analysis demonstrated that the good hypoglycemic effect of compounds 3 and 5 was achieved by activating PI3K/AKT signaling pathway to promote glucose consumption, glucose uptake, and glycogen synthesis. Furthermore, studies on molecular docking revealed the potent interactions between these bioactive substances and the PTP1B protein.
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
语种英语
出版者ACADEMIC PRESS INC ELSEVIER SCIENCE
WOS记录号WOS:001033482500001
源URL[http://119.78.100.183/handle/2S10ELR8/306827]  
专题中国科学院上海药物研究所
通讯作者Aisa, Haji Akber
作者单位1.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Chem Arid Zone, Urumqi 830011, Peoples R China
2.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, State Key Lab Basis Xinjiang Indigenous Med Plant, Urumqi 830011, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, Zhongshan Inst Drug Discovery, Zhongshan 528400, Guangdong, Peoples R China
推荐引用方式
GB/T 7714		 Tuohongerbieke, Amanguli,Liu, Liu,Li, Jun,et al. Root-Extracted lignanamides from Limonium gmelinii (Willd.) Kuntze with a potential PTP1B inhibitory activity by regulating PI3K/AKT signaling pathway[J]. BIOORGANIC CHEMISTRY,2023,132:9.
APA Tuohongerbieke, Amanguli,Liu, Liu,Li, Jun,Xin, Xuelei,&Aisa, Haji Akber.(2023).Root-Extracted lignanamides from Limonium gmelinii (Willd.) Kuntze with a potential PTP1B inhibitory activity by regulating PI3K/AKT signaling pathway.BIOORGANIC CHEMISTRY,132,9.
MLA Tuohongerbieke, Amanguli,et al."Root-Extracted lignanamides from Limonium gmelinii (Willd.) Kuntze with a potential PTP1B inhibitory activity by regulating PI3K/AKT signaling pathway".BIOORGANIC CHEMISTRY 132(2023):9.

入库方式： OAI收割

来源：上海药物研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。