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Orthogonally Engineered Albumin with Attenuated Macrophage Phagocytosis for the Targeted Visualization and Phototherapy of Liver Cancer

文献类型：期刊论文

作者Dou, Wei-Tao1,2,3; Qiu, Peng1,2,3; Shi, Yuanyuan4; Zhu, Ling1,2,3; Guo, Chen1,2,3; Li, Na5; Zang, Yi6,7; Liu, Tingting8; Zhao, Suwen8; Pan, Yufei4
刊名JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
出版日期2023-07-27
卷号145期号:31页码:17377-17388
ISSN号0002-7863
DOI10.1021/jacs.3c05052
通讯作者Sessler, Jonathan L.(Sessler@cm.utexas.edu) ; Tan, Yexiong(yxtan1214@163.com) ; Li, Jia(jli@simm.ac.cn) ; Wang, Hongyang(hywangk@vip.sina.com) ; He, Xiao-Peng(xphe@ecust.edu.cn)
英文摘要The five-year survival rate of hepatocellular carcinoma(HCC) remainsunsatisfactory. This reflects, in part, the paucity of effective methodsthat allow the target-specific diagnosis and therapy of HCC. Here,we report a strategy based on engineered human serum albumin (HSA)that permits the HCC-targeted delivery of diagnostic and therapeuticagents. Covalent cysteine conjugation combined with the exploitationof host-guest chemistry was used to effect the orthogonal functionalizationof HSA with two functionally independent peptides. One of these peptidestargets glypican-3 (GPC-3), an HCC-specific biomarker, while the secondreduces macrophage phagocytosis through immune-checkpoint stimulation.This orthogonally engineered HSA proved effective for the GPC-3-targeteddelivery of near-infrared fluorescent and phototherapeutic agents,thus permitting target-specific optical visualization and photodynamicablation of HCC in vivo. This study thus offers new insights intospecificity-enhanced fluorescence-guided surgery and phototherapyof HCC through the orthogonal engineering of biocompatible proteins.
WOS关键词HEPATOCELLULAR-CARCINOMA ; BIOMARKER DISCOVERY ; CELLS ; DOXORUBICIN ; GLYPICAN-3 ; DIAGNOSIS ; BINDING
资助项目National Natural Science Foundation of China[92253306] ; National Natural Science Foundation of China[82130099] ; National Natural Science Foundation of China[22107028] ; National Natural Science Foundation of China[U2230115] ; Shanghai Municipal Science and Technology Major Project[2018SHZDZX03] ; Science and Technology Commission of Shanghai Municipality[20JC1419400] ; Open Funding Project of the State Key Laboratory of Bioreactor Engineering of East China University of Science and Technology ; Fundamental Research Funds for the Central Universities[222201717003] ; Programme of Introducing Talents of Discipline to Universities[B16017] ; Robert A. Welch Foundation[F-0018]
WOS研究方向Chemistry
语种英语
出版者AMER CHEMICAL SOC
WOS记录号WOS:001037700000001
源URL[http://119.78.100.183/handle/2S10ELR8/306833]  
专题中国科学院上海药物研究所
通讯作者Sessler, Jonathan L.; Tan, Yexiong; Li, Jia; Wang, Hongyang; He, Xiao-Peng
作者单位1.East China Univ Sci & Technol, Frontiers Ctr Materiobiol & Dynam Chem, Sch Chem & Mol Engn, Key Lab Adv Mat, Shanghai 200237, Peoples R China
2.East China Univ Sci & Technol, Frontiers Ctr Materiobiol & Dynam Chem, Sch Chem & Mol Engn, Joint Int Res Lab Precis Chem & Mol Engn, Shanghai 200237, Peoples R China
3.East China Univ Sci & Technol, Joint Res Ctr, Frontiers Ctr Materiobiol & Dynam Chem, Sch Chem & Mol Engn, Shanghai 200237, Peoples R China
4.Second Mil Med Univ, Eastern Hepatobiliary Surg Inst, Natl Ctr Liver Canc, Int Cooperat Lab Signal Transduct, Shanghai 200433, Peoples R China
5.Chinese Acad Sci, Shanghai Adv Res Inst, Natl Facil Prot Sci Shanghai, Shanghai 201210, Peoples R China
6.Chinese Acad Sci, Shanghai Inst Mat Med, Natl Ctr Drug Screening, Shanghai 201203, Peoples R China
7.Lingang Lab, Shanghai 201203, Peoples R China
8.ShanghaiTech Univ, iHuman Inst, Shanghai 201210, Peoples R China
9.Univ Texas Austin, Dept Chem, Austin, TX 78712 USA
推荐引用方式
GB/T 7714		 Dou, Wei-Tao,Qiu, Peng,Shi, Yuanyuan,et al. Orthogonally Engineered Albumin with Attenuated Macrophage Phagocytosis for the Targeted Visualization and Phototherapy of Liver Cancer[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2023,145(31):17377-17388.
APA Dou, Wei-Tao.,Qiu, Peng.,Shi, Yuanyuan.,Zhu, Ling.,Guo, Chen.,...&He, Xiao-Peng.(2023).Orthogonally Engineered Albumin with Attenuated Macrophage Phagocytosis for the Targeted Visualization and Phototherapy of Liver Cancer.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,145(31),17377-17388.
MLA Dou, Wei-Tao,et al."Orthogonally Engineered Albumin with Attenuated Macrophage Phagocytosis for the Targeted Visualization and Phototherapy of Liver Cancer".JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 145.31(2023):17377-17388.

入库方式： OAI收割

来源：上海药物研究所

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