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Naringenin improves muscle endurance via activation of the Sp1-ERRg transcriptional axis

文献类型：期刊论文

作者Lv, Zhenyu6,9; Meng, Jiao9; Yao, Sheng5,6,7,8; Xiao, Fu3,4; Li, Shilong6,9; Shi, Haoyang6,9; Cui, Chen3,6; Chen, Kaixian3,4,6; Luo, Xiaomin3,4,6; Ye, Yang2,4,6,7,8
刊名CELL REPORTS
出版日期2023-11-28
卷号42期号:11页码:25
ISSN号2211-1247
DOI10.1016/j.celrep.2023.113288
通讯作者Luo, Xiaomin(xmluo@simm.ac.cn) ; Ye, Yang(yye@simm.ac.cn) ; Chen, Chang(changchen@moon.ibp.ac.cn)
英文摘要Skeletal muscle function declines in the aging process or disease; however, until now, skeletal muscle has remained one of the organs most undertreated with medication. In this study, naringenin (NAR) was found to build muscle endurance in wild-type mice of different ages by increasing oxidative myofiber numbers and aerobic metabolism, and it ameliorates muscle dysfunction in mdx mice. The transcription factor Sp1 was identified as a direct target of NAR and was shown to mediate the function of NAR on muscle. Moreover, the binding site of NAR on Sp1 was further validated as GLN-110. NAR enhances the binding of Sp1 to the CCCTGCCCTC sequence of the Esrrg promoter by promoting Sp1 phosphorylation, thus upregulating Esrrg expression. The identification of the Sp1-ERRg transcriptional axis is of great significance in basic muscle research, and this function of NAR has potential implications for the improvement of muscle function and the prevention of muscle atrophy.
WOS关键词PROTEIN-STRUCTURE ; SP1 ; PHOSPHORYLATION ; TESTOSTERONE ; EXPRESSION ; THERAPY ; DRUG
资助项目Ningxia Key Research and Development Program Grant[XDB39000000] ; Regional key projects of science and technology service network plan (STS plan) of Chinese Academy of Sciences[2016BZ05] ; National Natural Science Foundation of China[KFJ-STS-QYZD-181] ; Key Area Research and Development Program of Guangdong Province[82173696] ; [2020B030370002]
WOS研究方向Cell Biology
语种英语
出版者CELL PRESS
WOS记录号WOS:001096843100001
源URL[http://119.78.100.183/handle/2S10ELR8/307715]  
专题新药研究国家重点实验室
通讯作者Luo, Xiaomin; Ye, Yang; Chen, Chang
作者单位1.Capital Med Univ, Beijing Inst Brain Disorders, Beijing 100069, Peoples R China
2.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201203, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, Drug & Design Ctr, State Key Lab Drug Res, Shanghai 201203, Peoples R China
4.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Peoples R China
5.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan 528400, Peoples R China
6.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
7.Chinese Acad Sci, Shanghai Inst Mat Med, Nat Prod Chem Dept, Shanghai 201203, Peoples R China
8.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
9.Chinese Acad Sci, Inst Biophys, CAS Ctr Excellence Biomacromol, Natl Lab Biomacromol, Beijing 100101, Peoples R China
推荐引用方式
GB/T 7714		 Lv, Zhenyu,Meng, Jiao,Yao, Sheng,et al. Naringenin improves muscle endurance via activation of the Sp1-ERRg transcriptional axis[J]. CELL REPORTS,2023,42(11):25.
APA Lv, Zhenyu.,Meng, Jiao.,Yao, Sheng.,Xiao, Fu.,Li, Shilong.,...&Chen, Chang.(2023).Naringenin improves muscle endurance via activation of the Sp1-ERRg transcriptional axis.CELL REPORTS,42(11),25.
MLA Lv, Zhenyu,et al."Naringenin improves muscle endurance via activation of the Sp1-ERRg transcriptional axis".CELL REPORTS 42.11(2023):25.

入库方式： OAI收割

来源：上海药物研究所

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