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Multi-omics for COVID-19: driving development of therapeutics and vaccines

文献类型：期刊论文

作者Guo, Mengyu17,18; Xiong, Muya2,16; Peng, Jinying14; Guan, Tong2,17,18; Su, Haixia2,16; Huang, Yanyi3,4,10,15; Yang, Cai-Guang2,13; Li, Yang11,12; Boraschi, Diana7,11,12; Pillaiyar, Thanigaimalai5,6
刊名NATIONAL SCIENCE REVIEW
出版日期2023-08-09
卷号10期号:9页码:30
关键词COVID-19 SARS-CoV-2 multi-omics antibodies small-molecule drugs vaccines
ISSN号2095-5138
DOI10.1093/nsr/nwad161
通讯作者Wang, Guanbo(guanbo.wang@pku.edu.cn) ; Yi, Chengqi(chengqi.yi@pku.edu.cn) ; Xu, Yechun(ycxu@simm.ac.cn) ; Chen, Chunying(chenchy@nanoctr.cn)
英文摘要The ongoing COVID-19 pandemic caused by SARS-CoV-2 has raised global concern for public health and economy. The development of therapeutics and vaccines to combat this virus is continuously progressing. Multi-omics approaches, including genomics, transcriptomics, proteomics, metabolomics, epigenomics and metallomics, have helped understand the structural and molecular features of the virus, thereby assisting in the design of potential therapeutics and accelerating vaccine development for COVID-19. Here, we provide an up-to-date overview of the latest applications of multi-omics technologies in strategies addressing COVID-19, in order to provide suggestions towards the development of highly effective knowledge-based therapeutics and vaccines. Understanding the roles of multi-omics in COVID-19 facilitates the development of novel therapeutics and provides guidance for the rational design of vaccines.
WOS关键词POTENT NEUTRALIZING ANTIBODIES ; SARS-COV-2 INFECTION ; TRAINED IMMUNITY ; MUTATIONS ; RESPONSES ; EFFICACY ; ESCAPE ; IMMUNOGENICITY ; ESTABLISHMENT ; VACCINATION
资助项目National Natural Science Foundation of China[21974069] ; National Natural Science Foundation of China[91953201] ; Major Instrument Project of the National Natural Science Foundation of China[22027810] ; National Key R&D Program of the Ministry of Science and Technology of China[2021YFA1200900] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB36000000]
WOS研究方向Science & Technology - Other Topics
语种英语
WOS记录号WOS:001099867400001
出版者OXFORD UNIV PRESS
源URL[http://119.78.100.183/handle/2S10ELR8/307890]  
专题新药研究国家重点实验室
通讯作者Wang, Guanbo; Yi, Chengqi; Xu, Yechun; Chen, Chunying
作者单位1.GBA Natl Inst Nanotechnol Innovat, Guangzhou 510700, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Peking Univ, Coll Chem & Mol Engn, Beijing Natl Lab Mol Sci, Beijing, Peoples R China
4.Peking Univ, Peking Tsinghua Ctr Life Sci, Beijing 100871, Peoples R China
5.Eberhard Karls Univ Tubingen, Tuebingen Ctr Acad Drug Discovery, D-72076 Tubingen, Germany
6.Eberhard Karls Univ Tubingen, Inst Pharm, Pharmaceut Med Chem, D-72076 Tubingen, Germany
7.CNR, Inst Biochem & Cell Biol, I-80131 Naples, Italy
8.Peking Univ, Coll Chem & Mol Engn, Synthet & Funct Biomol Ctr, Beijing 100871, Peoples R China
9.Peking Univ, Coll Chem & Mol Engn, Dept Chem Biol, Beijing 100871, Peoples R China
10.Shenzhen Bay Lab, Inst Cell Anal, Shenzhen 528107, Peoples R China
推荐引用方式
GB/T 7714		 Guo, Mengyu,Xiong, Muya,Peng, Jinying,et al. Multi-omics for COVID-19: driving development of therapeutics and vaccines[J]. NATIONAL SCIENCE REVIEW,2023,10(9):30.
APA Guo, Mengyu.,Xiong, Muya.,Peng, Jinying.,Guan, Tong.,Su, Haixia.,...&Chen, Chunying.(2023).Multi-omics for COVID-19: driving development of therapeutics and vaccines.NATIONAL SCIENCE REVIEW,10(9),30.
MLA Guo, Mengyu,et al."Multi-omics for COVID-19: driving development of therapeutics and vaccines".NATIONAL SCIENCE REVIEW 10.9(2023):30.

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来源：上海药物研究所

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