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Development and validation of a sensitive liquid chromatography-tandem mass spectrometry method for the assay of 12 substances in rat plasma and its application to rat pharmacokinetics of Epimedium and Psoraleae Fructus herb pair after oral administration

文献类型：期刊论文

作者Wang, Linwei3,4; Yin, Xiaoying3,5; Liu, Huan4; Wang, Yangyang4; Li, Zhixiong4; Zhao, Yuxuan4; Xu, Haibo4; Huang, Chenggang2,4; Diao, Xingxing1,2,4
刊名JOURNAL OF SEPARATION SCIENCE
出版日期2024
卷号47期号:1页码:17
ISSN号1615-9306
关键词compatibility behaviors Epimedium LC-MS/MS pharmacokinetics Psoraleae Fructus
DOI10.1002/jssc.202300786
通讯作者Yin, Xiaoying(04160004@sues.edu.com) ; Huang, Chenggang(cghuang@simm.ac.cn) ; Diao, Xingxing(xxdiao@simm.ac.cn)
英文摘要Epimedium (EM) and Psoraleae Fructus (PF) are a traditional herb combination often used as a fixed form to treat osteoporosis disease in the clinic. However, the intricate interactions of this pair remain unknown. In our study, we undertook a comprehensive examination of their compatibility behaviors. Concurrently, a precise and sensitive quantitation method was successfully developed and validated using liquid chromatography-tandem mass spectrometry for the determination of 12 components. This method was applied in analyzing herbal extracts and biological samples (both in the portal vein and systemic plasma), which was also used to study the pharmacokinetics of the herb pair. The results indicated that the combination of EM and PF enhanced the dissolution of chemical components from PF in extracts, but it had a negligible influence on the contents of the components from EM. On the contrary, the in vivo exposure of the lowly exposed EM flavonoids significantly increased following the combination of EM and PF, whereas the highly exposed psoralen and isopsoralen were greatly reduced. These interactions might be crucial for the synergy and toxicity reduction of the herbal pair in disease treatment, which pave the way for further exploration into the clinical application and pharmacological mechanisms of EM and PF.
WOS关键词CHINESE ; INGREDIENTS ; ABSORPTION ; MEDICINE ; EXTRACT
资助项目National Key Research and Development Program of China[2022YFF1202600] ; National Key R&D Program of China[82373938] ; National Key R&D Program of China[81973453] ; National Natural Science Foundation of China[2023B1111030004] ; Key Technologies R&D Program of Guangdong Province
WOS研究方向Chemistry
语种英语
出版者WILEY-V C H VERLAG GMBH
WOS记录号WOS:001141555300001
源URL[http://119.78.100.183/handle/2S10ELR8/308687]  
专题中国科学院上海药物研究所
通讯作者Yin, Xiaoying; Huang, Chenggang; Diao, Xingxing
作者单位1.Xenofinder Co Ltd, Suzhou, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
3.Shanghai Univ Engn Sci, Coll Chem & Chem Engn, 333 Longteng Rd, Shanghai 201620, Shanghai, Peoples R China
4.Chinese Acad Sci, Shanghai Inst Mat Med, 501 Haike Rd, Shanghai 201203, Shanghai, Peoples R China
5.Shanghai Frontiers Sci Res Ctr Drug abil Cardiovas, Shanghai, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Linwei,Yin, Xiaoying,Liu, Huan,et al. Development and validation of a sensitive liquid chromatography-tandem mass spectrometry method for the assay of 12 substances in rat plasma and its application to rat pharmacokinetics of Epimedium and Psoraleae Fructus herb pair after oral administration[J]. JOURNAL OF SEPARATION SCIENCE,2024,47(1):17.
APA Wang, Linwei.,Yin, Xiaoying.,Liu, Huan.,Wang, Yangyang.,Li, Zhixiong.,...&Diao, Xingxing.(2024).Development and validation of a sensitive liquid chromatography-tandem mass spectrometry method for the assay of 12 substances in rat plasma and its application to rat pharmacokinetics of Epimedium and Psoraleae Fructus herb pair after oral administration.JOURNAL OF SEPARATION SCIENCE,47(1),17.
MLA Wang, Linwei,et al."Development and validation of a sensitive liquid chromatography-tandem mass spectrometry method for the assay of 12 substances in rat plasma and its application to rat pharmacokinetics of Epimedium and Psoraleae Fructus herb pair after oral administration".JOURNAL OF SEPARATION SCIENCE 47.1(2024):17.

入库方式： OAI收割

来源：上海药物研究所

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