Selectivity Comparison of Tumor-Imaging Probes Designed Based on Various Tumor-Targeting Strategies: A Proof of Concept Study
文献类型：期刊论文
| 作者 | Guo, Rui-Ying1; Wang, Han-Min2,3; Dong, Xiaowu1; Hu, Yongzhou1; Li, Jia2,3,4 ; Zang, Yi2,3; Li, Xin1
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| 刊名 | ACS applied bio materials
 |
| 出版日期 | 2021-03-15 |
| 卷号 | 4期号:3页码:2058-2065 |
| 关键词 | fluorescence imaging fluorescent probe imaging contrast receptor tumor tumor microenvironment |
| ISSN号 | 2576-6422 |
| DOI | 10.1021/acsabm.0c01097 |
| 文献子类 | Article |
| 英文摘要 | Fluorescence probes are emerging as appealing tools for tumor imaging, although the discovery of ideal probes with high tumor selectivity and desirable tumor-to-normal contrast remains challenging. There are currently two strategies used for designing tumor-targeted probes. One is employing tumor-targeting agents and the other is tumor-microenvironment-activatable probes. Although these two strategies have been widely explored, there are few reports on the comparison of probe performance designed based on the two strategies. Herein, by targeting somatostatin receptors (SSTR) overexpressed in neuroendocrine tumors with octreotide (OCT), we have designed two probes, with probe P5 being tumor-microenvironment-activatable and P5cc3 having fluorescence always on. A comparison of their selectivity toward tumor cells over SSTR-expressing normal cells demonstrated that these two probes showed a similar degree of tumor selectivity, whereas the activatable probe P5 showed enhanced tumor-to-normal imaging contrast due to its tumor-microenvironment-activatable fluorescence. Our results consolidate the rationality of either strategy for designing tumor-targeted imaging agents, and highlight the activatable strategy as a feasible way of enhancing tumor-to-normal imaging contrast. |
| 语种 | 英语 |
| WOS记录号 | MEDLINE:35014332 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/309292]  |
| 专题 | 新药研究国家重点实验室 |
| 作者单位 | 1.College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.; 2.State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.; 3.University of Chinese Academy of Sciences, Beijing 100049, China.; 4.Open Studio for Druggability Research of Marine Natural Products, Pilot National Laboratory for Marine Science and Technology (Qingdao), 1 Wenhai Road, Aoshanwei, Jimo, Qingdao 266237, China. |
| 推荐引用方式 GB/T 7714 | Guo, Rui-Ying,Wang, Han-Min,Dong, Xiaowu,et al. Selectivity Comparison of Tumor-Imaging Probes Designed Based on Various Tumor-Targeting Strategies: A Proof of Concept Study[J]. ACS applied bio materials,2021,4(3):2058-2065. |
| APA | Guo, Rui-Ying.,Wang, Han-Min.,Dong, Xiaowu.,Hu, Yongzhou.,Li, Jia.,...&Li, Xin.(2021).Selectivity Comparison of Tumor-Imaging Probes Designed Based on Various Tumor-Targeting Strategies: A Proof of Concept Study.ACS applied bio materials,4(3),2058-2065. |
| MLA | Guo, Rui-Ying,et al."Selectivity Comparison of Tumor-Imaging Probes Designed Based on Various Tumor-Targeting Strategies: A Proof of Concept Study".ACS applied bio materials 4.3(2021):2058-2065. |
入库方式： OAI收割
来源：上海药物研究所
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