Preventive and therapeutic benefits of nelfinavir in rhesus macaques and human beings infected with SARS-CoV-2
文献类型：期刊论文
| 作者 | Xu, Zhijian8,9,10 ; Shi, Danrong7; Han, Jianbao6; Ling, Yun5; Jiang, Xiangrui8,10; Lu, Xiangyun7; Li, Chuan(1.3); Gong, Likun4,8,10; Ge, Guangbo3; Zhang, Yani3
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| 刊名 | Signal Transduction and Targeted Therapy
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| 出版日期 | 2023-04-24 |
| 卷号 | 8期号:5页码:2384-2391 |
| ISSN号 | 2095-9907 |
| DOI | 10.1038/s41392-023-01429-0 |
| 文献子类 | Article |
| 英文摘要 | Effective drugs with broad spectrum safety profile to all people are highly expected to combat COVID-19 caused by SARS-CoV-2. Here we report that nelfinavir, an FDA approved drug for the treatment of HIV infection, is effective against SARS-CoV-2 and COVID-19. Preincubation of nelfinavir could inhibit the activity of the main protease of the SARS-CoV-2(IC_(50) = 8.26 M), while its antiviral activity in Vero E6 cells against a clinical isolate of SARS-CoV-2 was determined to be 2.93 M(EC_(50)). In comparison with vehicle-treated animals, rhesus macaque prophylactically treated with nelfinavir had significantly lower temperature and significantly reduced virus loads in the nasal and anal swabs of the animals. At necropsy, nelfinavir-treated animals had a significant reduction of the viral replication in the lungs by nearly three orders of magnitude. A prospective clinic study with 37 enrolled treatment-naive patients at Shanghai Public Health Clinical Center, which were randomized(1:1)to nelfinavir and control groups, showed that the nelfinavir treatment could shorten the duration of viral shedding by 5.5 days(9.0 vs. 14.5 days, P = 0.055)and the duration of fever time by 3.8 days(2.8 vs. 6.6 days, P = 0.014)in mild/moderate COVID-19 patients. The antiviral efficiency and clinical benefits in rhesus macaque model and in COVID-19 patients, together with its well-established good safety profile in almost all ages and during pregnancy, indicated that nelfinavir is a highly promising medication with the potential of preventative effect for the treatment of COVID-19. |
| 语种 | 英语 |
| CSCD记录号 | CSCD:7473025 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/309632]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Shen, Jingshan; Zhang, Jianliang; Zheng, Yongtang; Yao, Hangping; Zhu, Weiliang |
| 作者单位 | 1.Jinan Microecological Biomedicine Shandong Laboratory, Jinan 250117, China 2.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China; 3.Shanghai Frontiers Science Center of TCM Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; 4.Center for Drug Safety Evaluation and Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; 5.Department of Infectious Disease, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China; 6.Kunming National High-level Biosafety Research Center for Non-human Primates, Center for Biosafety Mega-Science, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650107, China; 7.State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China; 8.School of Pharmacy, University of Chinese Academy of Sciences, Beijing 100049, China; 9.Drug Discovery and Design Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; 10.State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; |
| 推荐引用方式 GB/T 7714 | Xu, Zhijian,Shi, Danrong,Han, Jianbao,et al. Preventive and therapeutic benefits of nelfinavir in rhesus macaques and human beings infected with SARS-CoV-2[J]. Signal Transduction and Targeted Therapy,2023,8(5):2384-2391. |
| APA | Xu, Zhijian.,Shi, Danrong.,Han, Jianbao.,Ling, Yun.,Jiang, Xiangrui.,...&Zhu, Weiliang.(2023).Preventive and therapeutic benefits of nelfinavir in rhesus macaques and human beings infected with SARS-CoV-2.Signal Transduction and Targeted Therapy,8(5),2384-2391. |
| MLA | Xu, Zhijian,et al."Preventive and therapeutic benefits of nelfinavir in rhesus macaques and human beings infected with SARS-CoV-2".Signal Transduction and Targeted Therapy 8.5(2023):2384-2391. |
入库方式： OAI收割
来源：上海药物研究所
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