Discovery of Polyphenolic Natural Products as SARS-CoV-2 Mpro Inhibitors for COVID-19
文献类型：期刊论文
| 作者 | Kruger, Nadine7; Kronenberger, Thales4,5,6; Xie, Hang3; Rocha, Cheila2,7; Pohlmann, Stefan2,7; Su, Haixia1; Xu, Yechun1,3 ; Laufer, Stefan A. A.4,5,6; Pillaiyar, Thanigaimalai5,6
|
| 刊名 | PHARMACEUTICALS
 |
| 出版日期 | 2023-02-01 |
| 卷号 | 16期号:2页码:190 |
| 关键词 | antivirals coronavirus COVID-19 covalent drugs dynamic light scattering inhibitors main protease natural products |
| DOI | 10.3390/ph16020190 |
| 文献子类 | Article |
| 英文摘要 | The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has forced the development of direct-acting antiviral drugs due to the coronavirus disease 2019 (COVID-19) pandemic. The main protease of SARS-CoV-2 is a crucial enzyme that breaks down polyproteins synthesized from the viral RNA, making it a validated target for the development of SARS-CoV-2 therapeutics. New chemical phenotypes are frequently discovered in natural goods. In the current study, we used a fluorogenic assay to test a variety of natural products for their ability to inhibit SARS-CoV-2 M-pro. Several compounds were discovered to inhibit M-pro at low micromolar concentrations. It was possible to crystallize robinetin together with SARS-CoV-2 M-pro, and the X-ray structure revealed covalent interaction with the protease's catalytic Cys145 site. Selected potent molecules also exhibited antiviral properties without cytotoxicity. Some of these powerful inhibitors might be utilized as lead compounds for future COVID-19 research. |
| WOS关键词 | MAIN PROTEASE ; KAPPA-B ; SARS ; ORIDONIN ; PREDICTION ; EPIGALLOCATECHIN-3-GALLATE ; IDENTIFICATION ; CYTOKINES ; SOFTWARE ; PATHWAYS |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000941591700001 |
| 出版者 | MDPI |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/309711]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Xu, Yechun; Pillaiyar, Thanigaimalai |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Georg August Univ Gottingen, Fac Biol & Psychol, D-37073 Gottingen, Germany; 3.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Peoples R China; 4.Univ Tubingen, Cluster Excellence iFIT EXC Image Guided & Funct, D-72076 Tubingen, Germany; 5.Eberhard Karls Univ Tubingen, Tubingen Ctr Acad Drug Discovery, Morgenstelle 8, D-72076 Tubingen, Germany; 6.Eberhard Karls Univ Tubingen, Inst Pharm Pharmaceut Med Chem, Morgenstelle 8, D-72076 Tubingen, Germany; 7.Leibniz Inst Primate Res Gottingen, German Primate Ctr, Infect Biol Unit, Kellnerweg 4, D-37077 Gottingen, Germany; |
| 推荐引用方式 GB/T 7714 | Kruger, Nadine,Kronenberger, Thales,Xie, Hang,et al. Discovery of Polyphenolic Natural Products as SARS-CoV-2 Mpro Inhibitors for COVID-19[J]. PHARMACEUTICALS,2023,16(2):190. |
| APA | Kruger, Nadine.,Kronenberger, Thales.,Xie, Hang.,Rocha, Cheila.,Pohlmann, Stefan.,...&Pillaiyar, Thanigaimalai.(2023).Discovery of Polyphenolic Natural Products as SARS-CoV-2 Mpro Inhibitors for COVID-19.PHARMACEUTICALS,16(2),190. |
| MLA | Kruger, Nadine,et al."Discovery of Polyphenolic Natural Products as SARS-CoV-2 Mpro Inhibitors for COVID-19".PHARMACEUTICALS 16.2(2023):190. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。