Three new feruloyl glucuronopyranosyl glycerols from Eriocaulon buergerianum with their anti-fibrotic effects on hepatic stellate cells
文献类型：期刊论文
| 作者 | Zhang, Yong4,5,6; Li, Hao3; Xu, Zhijian4,5 ; Shi, Yulong4,5; Li, Bo4,5; Li, Jia1,2,4; Aisa, Haji Akber4,6; Zang, Yi1,2,3,4; Zhu, Weiliang4,5
|
| 刊名 | NATURAL PRODUCT RESEARCH
 |
| 出版日期 | 2023-03-19 |
| 卷号 | 37期号:6页码:956-966 |
| 关键词 | Eriocaulon buergerianum Eriocaulaceae feruloyl glucuronopyranosyl glycerols TGF-beta 1 receptor hepatic fibrosis |
| DOI | 10.1080/14786419.2022.2099387 |
| 文献子类 | Article |
| 英文摘要 | Three new feruloyl glucuronopyranosyl glycerols, 1-O-alpha-D-(2'-feru-loyl) glucuronopyranosyl glycerol (1), 1-O-alpha-D-(3' feruloyl) glucuro- nopyranosyl glycerol (2), and 1-O-alpha-D-(4'-feruloyl) glucuro-nopyranosyl glycerol (3) were isolated and purified from the capitulum of Eriocaulon buergerianum Koern. Their structures were identified by spectroscopic and chemical methods. Molecular docking study showed that 1 is a potential inhibitor of TGF-beta 1 receptor. Bioassay results revealed that 1 exhibited strong inhibitory activity against the TGF-beta-induced expression of cc-smooth muscle actin (alpha-SMA) and fibronectin in human hepatic stellate LX-2 cells. The results in this study indicated that the new feruloyl glucuronopyranosyl glycerol 1 has preventive and therapeutic potentials against hepatic fibrosis. |
| WOS关键词 | LIVER FIBROSIS ; ACCURATE DOCKING ; FLAVONOIDS ; ACTIVATION ; MECHANISMS ; GLYCOSIDES ; GLIDE |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000825462300001 |
| 出版者 | TAYLOR & FRANCIS LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/309727]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Zang, Yi; Zhu, Weiliang |
| 作者单位 | 1.Pilot Natl Lab Marine Sci & Technol Qingdao, Open Studio Druggabil Res Marine Nat Prod, Qingdao, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai, Peoples R China; 3.Nanjing Univ Chinese Med, Sch Chinese Mat Medica, Nanjing, Peoples R China; 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China; 5.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, Stake Key Lab Drug Res, Shanghai 201203, Peoples R China; 6.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, CAS Lab Chem Plant Resources Arid Reg, State Key Lab Basis Xinjiang Indigenous Med Plant, Urumqi, Xinjiang, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Zhang, Yong,Li, Hao,Xu, Zhijian,et al. Three new feruloyl glucuronopyranosyl glycerols from Eriocaulon buergerianum with their anti-fibrotic effects on hepatic stellate cells[J]. NATURAL PRODUCT RESEARCH,2023,37(6):956-966. |
| APA | Zhang, Yong.,Li, Hao.,Xu, Zhijian.,Shi, Yulong.,Li, Bo.,...&Zhu, Weiliang.(2023).Three new feruloyl glucuronopyranosyl glycerols from Eriocaulon buergerianum with their anti-fibrotic effects on hepatic stellate cells.NATURAL PRODUCT RESEARCH,37(6),956-966. |
| MLA | Zhang, Yong,et al."Three new feruloyl glucuronopyranosyl glycerols from Eriocaulon buergerianum with their anti-fibrotic effects on hepatic stellate cells".NATURAL PRODUCT RESEARCH 37.6(2023):956-966. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。